The numerous endogenous opioid peptides (β‐endorphin, enkephalins, dynorphins…) and
the exogenous opioids (such as morphine) exert their effects through the activation of …

The multiplicity of opioid receptors ([mu],[delta], k) and the limited knowledge of their coupling
mechanisms explain why cellular and biochemical changes underlying opioid tolerance/…

The myelin-deficient mutant Shiverer (Shi/Shi) lacks basic protein (MBP) in the myelin of its
central nervous system (CNS). Less than 3% of the normal content in MBP is present in a …

Keeping in mind the increased pain complaints reported in anxious or depressive patients,
our goal was to investigate in rats the consequences of an experimentally provoked state of …

Rheumatoid arthritis is characterized by erosive inflammation of the joints, new bone proliferation,
and ankylosis, leading to severely reduced locomotion and intense chronic pain. In a …

To measure the prevalence and intensity of pain in hospitalized patients and to assess the
quality of pain management, an exhaustive cross-sectional study was conducted in every …

Circadian changes in plasma levels of melatonin, prolactin, LH and FSH were studied in
four groups: seven healthy young men, six elderly men, six elderly women and six elderly …

Trigeminal neuropathic pain represents a real challenge to therapy because commonly
used drugs are devoid of real beneficial effect or patients frequently become intolerant or …

The central mechanism responsible for the potentiation by antidepressant drugs of analgesia
induced by morphine, was explored by measuring the levels of various neuropeptides (met-…

Substance P-like immunoreactivity was measured in the basal ganglia of controls and
parkinsonian patients. A significant decrease in substance P-like immunoreactivity was observed …