… Elion and published in Les Prix Nobel 1988, printed in Sweden by Norstedts Tryckeri,
Stockholm, Sweden, 1989, republished here with the permission of the Nobel Foundation, the …

… Clair MH, Furman PA, Lubbers GM, Elion GB: Inhibition of … Clair MH, Elion GB: Metabolism
of acyclovir in virus-infected and … Elion GEJ: The chemotherapeutic exploitation of virus-…

… Krasny,and GB Elion, unpublished). A studywas, therefore, undertaken to determine the basis
… Elion, unpublished). It was identical in all respects with the triphosphate isolated by high-…

… ) reported here is one of five VZV strains which were examined for induction of ACV-TP
formation in WI-38 cells; substantial amounts of ACV-TP were found in each case (Biron & Elion, …

The reasons for acyclovir's activity and selectivity in cells infected with HSV or VZV may be
summarized as follows: 1. Activation by a HSV- or VZV-specified TK. 2. Greater sensitivity of …

articles Page 1 Nature Vol. 272 13 April 1978 articles AS m 583 9-(2-Hydroxyethoxymethyl)guanine
activity against viruses of the herpes group HJ Schaeffer, Lilia Beauchamp, P. de Miranda & …

A method is described for representing, either graphically or numerically, synergism between
bacterial antagonists. The effects of various combinations of antagonists of folie acid, …

… Samples of SK 5357, con forming in chemical purity to the synthetic products described by
Elion el al. (8), were used as the monohydrate and as the anhydrous base; all doses were …

Allopurinol and other 6-unsubstituted pyrazolo[3,4-d]-pyrimidines have been shown to reduce
all of the oxidation-reduction reactive groups of milk xanthine oxidase. The great inhibitory …

The metabolic disposition of allopurinol [4-hydroxypyrazolo(3,4-d)-pyrimidine) was determined
in mice, dogs, and human subjects. The drug is a substrate for, as well as an inhibitor of, …