This summary article presents an overview of the molecular relationships among the voltage-gated
potassium channels and a standard nomenclature for them, which is derived from the …

The renalase pathway is a previously unrecognized mechanism for regulating cardiac
function and blood pressure. In this pathway, renalase, a novel secreted amine oxidase that is …

Renalase is a novel flavoprotein, highly expressed in kidney and heart, which metabolizes
catecholamines and catecholamine-like substances via a superoxide (O2 – )-dependent …

The kidney not only regulates fluid and electrolyte balance but also functions as an endocrine
organ. For instance, it is the major source of circulating erythropoietin and renin. Despite …

Background— We previously identified renalase, a secreted novel amine oxidase that
specifically degrades circulating catecholamines. Parenteral administration of either native or …

Kv1.3 is a voltage-gated potassium (K) channel expressed in a number of tissues, including
fat and skeletal muscle. Channel inhibition improves experimental autoimmune encephalitis, …

Voltage-gated potassium (Kv) channels regulate cell membrane potential and control a
variety of cellular processes. Kv1.3 channels are expressed in several tissues and believed to …

Chronic kidney disease (CKD) leads to an 18-fold increase in cardiovascular complications
not fully explained by traditional risk factors. Levels of renalase, a recently discovered …

Background Blood pressure is acutely regulated by the sympathetic nervous system through
the action of vasoactive hormones such as epinephrine, norepinephrine, and dopamine. …

Gitelman’s syndrome is an autosomal recessive disorder of salt wasting and hypokalemia
caused by mutations in the thiazide-sensitive Na-Cl cotransporter. To investigate the …