Orthomyxovirus replication, transcription, and polyadenylation

G Neumann, GG Brownlee, E Fodor… - Biology of Negative Strand …, 2004 - Springer
Efficient in vitro and in vivo systems are now in place to study the role of viral proteins in
replication and/or transcription, the regulation of these processes, polyadenylation of viral …

Recognition of mRNA cap structures by viral and cellular proteins

P Fechter, GG Brownlee - Journal of General Virology, 2005 - microbiologyresearch.org
Most cellular and eukaryotic viral mRNAs have a cap structure at their 5′ end that is critical
for efficient translation. Cap structures also aid in mRNA transport from nucleus to cytoplasm …

3′ non-coding region sequences in eukaryotic messenger RNA

NJ Proudfoot, GG Brownlee - Nature, 1976 - nature.com
The sequence A–A–U–A–A–A is present in six different purified messenger RNA molecules
(specifically the α- and β-globulin mRNAs of rabbit and human, the immunoglobulin light …

A two-dimensional fractionation procedure for radioactive nucleotides

F Sanger, GG Brownlee, BG Barrell - Journal of molecular biology, 1965 - Elsevier
A method is described for the two-dimensional fractionation of ribonuclease digests of 32 P-labelled
RNA. High-voltage ionophoresis is used in both dimensions. The first is on cellulose …

The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype)

AJ Caton, GG Brownlee, JW Yewdell, W Gerhard - Cell, 1982 - cell.com
We have constructed an operational antigenic map of the hemagglutinin of influenza virus A/PR/8/34,
which indicates the presence of five immunodominant antigenic regions exhibiting …

Rescue of influenza A virus from recombinant DNA

…, OG Engelhardt, P Palese, GG Brownlee… - Journal of …, 1999 - Am Soc Microbiol
We have rescued influenza A virus by transfection of 12 plasmids into Vero cells. The eight
individual negative-sense genomic viral RNAs were transcribed from plasmids containing …

A possible precursor of immunoglobulin light chains

C Milstein, GG Brownlee, TM Harrison… - Nature New Biology, 1972 - nature.com
… (PAM was modified from Guthrie and Sinsheimer" and contained per litre: 10 g casamino
acids, 8 g nutrient broth, 100 g sucrose and 2 g MgSO, added after autoclaving) After another …

A pseudogene structure in 5S DNA of Xenopus laevis

C Jacq, JR Miller, GG Brownlee - Cell, 1977 - Elsevier
… Early sequence studies of Brownlee, … and were analyzed previously (Brownlee … previously
seen by Brownlee et al. (1974) in their studies of the …

The structure of a Ca2+-binding epidermal growth factor-like domain: its role in protein-protein interactions

Z Rao, P Handford, M Mayhew, V Knott, GG Brownlee… - Cell, 1995 - Elsevier
Various diverse extracellular proteins possess Ca 2+ -binding epidermal growth factor (EGF)-like
domains, the function of which remains uncertain. We have determined, at high …

Direct evidence that the poly (A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template

…, DC Pritlove, E Fodor, GG Brownlee - Journal of virology, 1999 - Am Soc Microbiol
The poly(A) tail of influenza virus mRNA is thought to be synthesized by reiterative copying
of the U track near the 5′ end of the virion RNA template. This has been widely accepted as …