User profiles for G. Semple

Malcolm G Semple

Professor of Child Health and Outbreak Medicine, University of Liverpool
Verified email at liverpool.ac.uk
Cited by 34820

International union of basic and clinical pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and …

…, SL Colletti, TW Lovenberg, G Semple… - Pharmacological …, 2011 - ASPET
The G-protein-coupled receptors GPR81, GPR109A, and GPR109B share significant sequence
homology and form a small group of receptors, each of which is encoded by clustered …

A role for β-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release

…, D Unett, Y Liang, K Demarest, G Semple… - …, 2007 - academic.oup.com
Pancreatic β-cell dysfunction is a hallmark event in the pathogenesis of type 2 diabetes.
Injectable peptide agonists of the glucagon-like peptide 1 (GLP-1) receptor have shown …

Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression

…, X Liu, L Jin, K Wu, PD Boatman, G Semple… - Science translational …, 2012 - science.org
… It is well established that activation of the seven-transmembrane G i -coupled receptor
GPR109A on Langerhans cells results in release of prostaglandin D 2 , which mediates the well-…

GnRH Antagonists:  A New Generation of Long Acting Analogues Incorporating p-Ureido-phenylalanines at Positions 5 and 6

…, P Broqua, A Aebi, ML Aubert, G Semple… - Journal of medicinal …, 2001 - ACS Publications
… The fragment was assembled manually on 2.0 g of 0.60 mmol/g substituted Boc-Pro-Merrifield
resin that was prepared in-house using the classical method. The completed peptide-…

Anxiolytic-and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists

…, Y Sekiguchi, S Okuyama, TA Tran, G Semple… - … of Pharmacology and …, 2005 - ASPET
Melanin-concentrating hormone (MCH) is a cyclic peptide produced in the lateral
hypothalamus. It has been implicated in a number of physiological processes including feeding …

Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119

G Semple, B Fioravanti, G Pereira… - Journal of medicinal …, 2008 - ACS Publications
GPR119 is a rhodopsin-like GPCR expressed in pancreatic β-cells and incretin releasing
cells in the GI tract. As with incretins, GPR119 increases cAMP levels in these cell types, thus …

[HTML][HTML] A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a …

…, M Roderick, BR Scholefield, MG Semple… - The Lancet Child & …, 2021 - thelancet.com
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS)
is a novel condition that was first reported in April, 2020. We aimed to develop a national …

[HTML][HTML] Nicotinic acid receptor agonists differentially activate downstream effectors

…, P Ornelas, MG Waters, SD Wright, G Semple… - Journal of Biological …, 2007 - ASBMB
Nicotinic acid remains the most effective therapeutic agent for the treatment and prevention
of atherosclerosis resulting from low high density lipoprotein cholesterol. The therapeutic …

Distribution of pacemaker function through the tunica muscularis of the canine gastric antrum

K Horiguchi, GSA Semple, KM Sanders… - The Journal of …, 2001 - Wiley Online Library
G and H are montages of circular and longitudinal muscle slivers, respectively. G reveals
circular IC-IM located within smooth muscle bundles (arrowheads). Occasional ICC (IC-SEP; …

(3R)-N-(1-(tert-Butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H- 1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476):  A Potent and Orally …

G Semple, H Ryder, DP Rooker, AR Batt… - Journal of medicinal …, 1997 - ACS Publications
… However, prolonged inhibition of secretion with either of these agents causes continuous
stimulation of G-cells, resulting in hypergastrinaemia which is believed to lead to hyperplasia of …