Guanylyl cyclases and signaling by cyclic GMP
…, GM Pitari, S Kazerounian, I Ruiz-Stewart… - Pharmacological …, 2000 - ASPET
Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The
family comprises both membrane-bound and soluble isoforms that are expressed in nearly …
family comprises both membrane-bound and soluble isoforms that are expressed in nearly …
Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism
I Ruiz-Stewart, SR Tiyyagura, JE Lin… - Proceedings of the …, 2004 - National Acad Sciences
Defending cellular integrity against disturbances in intracellular concentrations of ATP ([ATP]
i ) is predicated on coordinating the selection of substrates and their flux through metabolic …
i ) is predicated on coordinating the selection of substrates and their flux through metabolic …
Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins
…, FJ Shah, GS Frick, M Madesh, I Ruiz-Stewart… - … of Pharmacology and …, 2005 - ASPET
Guanylyl cyclase C and accumulation of cGMP induced by bacterial heat-stable enterotoxins
(STs) promote colon cancer cell cytostasis, serving as a tumor suppressor in intestine. …
(STs) promote colon cancer cell cytostasis, serving as a tumor suppressor in intestine. …
Nitric oxide activation of soluble guanylyl cyclase reveals high and low affinity sites that mediate allosteric inhibition by calcium
S Kazerounian, GM Pitari, I Ruiz-Stewart, S Schulz… - Biochemistry, 2002 - ACS Publications
Cyclic GMP (cGMP) and Ca 2+ regulate opposing mechanisms in (patho)physiological
processes reflected in the reciprocal regulation of their intracellular concentrations. Although …
processes reflected in the reciprocal regulation of their intracellular concentrations. Although …
Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2‐substituted adenine nucleotides
I Ruiz‐Stewart, S Kazerounian, GM Pitari… - European journal of …, 2002 - Wiley Online Library
Nitric oxide (NO), the principal endogenous ligand for soluble guanylate cyclase (sGC),
stimulates that enzyme and accumulation of intracellular cGMP, which mediates many of the (…
stimulates that enzyme and accumulation of intracellular cGMP, which mediates many of the (…
Adenine nucleotide regulation of soluble guanylyl cyclase: Coupling nitric oxide signaling to cell metabolism
I Ruiz-Stewart - 2004 - search.proquest.com
Soluble guanylyl cyclase (sGC), a subtype of the guanylyl cyclase family of enzymes, is
endogenously expressed in many tissue types and is responsible for mediating many (patho) …
endogenously expressed in many tissue types and is responsible for mediating many (patho) …
Soluble guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism
SR Tiyyagura, I Ruiz‐Stewart… - Clinical …, 2004 - Wiley Online Library
Defending cellular integrity against disturbances in intracellular concentrations of ATP ([ATP]
i ) is predicated upon coordinating the selection of substrates and their flux through …
i ) is predicated upon coordinating the selection of substrates and their flux through …
Mitogenic CA2+ entry through ICRAC channels reciprocally regulates the tumor suppressor guanylyl cyclase C (GCC)
…, FJ Shah, M Madesh, I Ruiz‐Stewart… - Clinical …, 2004 - Wiley Online Library
Guanylyl cyclase C (GCC) through cyclic GMP (cGMP) inhibits colorectal cancer cell
proliferation, serving as a tumor suppressor in intestine. Conversely, Ca 2+ entry through calcium …
proliferation, serving as a tumor suppressor in intestine. Conversely, Ca 2+ entry through calcium …
[CITATION][C] Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, and Waldman SA
KA Lucas - Guanylyl cyclases and signaling by cyclic GMP …, 2000
[CITATION][C] Ruiz-Stewart l, Park J, Schulz S, Chepenik K, Waldman SA. Guanylyl Cyclases and Signaling by Cyclic GMP
K Lucas, C Pitari, S Kazcrounian - Pharmacol Rev, 2000