Glucocorticoids: exemplars of multi‐tasking

JC Buckingham - British journal of pharmacology, 2006 - Wiley Online Library
Well over 80 years ago Philip Smith described the beneficial clinical effects of adrenocortical
extracts in animal models of adrenal insufficiency. In the ensuing years, scientists across …

Cytokines: regulation of the hypothalamo–pituitary–adrenocortical axis

CD John, JC Buckingham - Current opinion in pharmacology, 2003 - Elsevier
Many of the pro-inflammatory cytokines that are released in response to immune/inflammatory
insults exert marked stimulatory influences on the hypothalamo–pituitary–adrenocortical …

Annexin A1 in the brain–undiscovered roles?

…, H Christian, F Gavins, JC Buckingham… - Trends in …, 2008 - cell.com
Annexin A1 (ANXA1) is an endogenous protein known to have potent anti-inflammatory
properties in the peripheral system. It has also been detected in the brain, but its function there is …

Aberrant inflammation and resistance to glucocorticoids in Annexin 1−/− Mouse

…, M Perretti, JF Morris, JC Buckingham… - The FASEB …, 2003 - Wiley Online Library
The 37‐kDa protein annexin 1 (Anx‐1; lipocortin 1) has been implicated in the regulation of
phagocytosis, cell signaling, and proliferation and is postulated to be a mediator of …

Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation

…, M Gray, F D'Acquisto, JC Buckingham… - The Journal of …, 2010 - journals.aai.org
The human formyl-peptide receptor (FPR)-2 is a G protein-coupled receptor that transduces
signals from lipoxin A 4, annexin A1, and serum amyloid A (SAA) to regulate inflammation. In …

A novel calcium‐dependent proapoptotic effect of annexin 1 on human neutrophils

…, A Kamal, F Russo-Marie, JC Buckingham… - The FASEB …, 2003 - Wiley Online Library
The glucocorticoid‐inducible protein annexin (ANXA) 1 is an anti‐inflammatory mediator
that down‐regulates the host response. Endogenously, ANXA1 is released in large amounts …

Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic …

…, HC Christian, RJ Flower, JC Buckingham - …, 2003 - academic.oup.com
Our recent studies on rat pituitary tissue suggest that the annexin 1 (ANXA1)-dependent
inhibitory actions of glucocorticoids on ACTH secretion are effected via a paracrine mechanism …

Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen‐induced arthritis

…, S Yona, R Hannon, JC Buckingham… - Arthritis & …, 2004 - Wiley Online Library
Objective Annexin 1 (Anx‐1) is a putative mediator of the antiinflammatory actions of
glucocorticoids (GCs). This study investigated the role of Anx‐1 in experimental arthritis and in GC‐…

The effect of pregnancy and labor on the human cervix: changes in collagen, glycoproteins, and glycosaminoglycans

…, M Breen, HG Weinstein, JC Buckingham… - American journal of …, 1974 - Elsevier
Full-thickness samples of the cervix were obtained from hysterectomy specimens of
nonpregnant women of childbearing age for comparison with similar specimens taken from the …

[HTML][HTML] Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface

…, T Tierney, RJ Flower, JC Buckingham - The FASEB journal …, 2006 - ncbi.nlm.nih.gov
Annexin A1 (ANXA1) has an important role in cell-cell communication in the host defense
and neuroendocrine systems. In both systems, its actions are exerted extracellularly via …