Rat models of type 1 diabetes: genetics, environment, and autoimmunity
JP Mordes, R Bortell, EP Blankenhorn, AA Rossini… - ILAR …, 2004 - academic.oup.com
For many years, the vast amount of data gathered from analysis of nonobese diabetic (NOD)
and congenic NOD mice has eclipsed interest in the rat for the study of type 1 diabetes. The …
and congenic NOD mice has eclipsed interest in the rat for the study of type 1 diabetes. The …
Implications of using hemoglobin A1C for diagnosing diabetes mellitus
S Malkani, JP Mordes - The American journal of medicine, 2011 - Elsevier
Until 2010, the diagnosis of diabetes mellitus was based solely on glucose concentration,
but the American Diabetes Association (ADA) recommendations now include a new criterion: …
but the American Diabetes Association (ADA) recommendations now include a new criterion: …
Immunology of insulin-dependent diabetes mellitus
AA Rossini, JP Mordes, AA Like - Annual review of immunology, 1985 - annualreviews.org
… This model of diabetes was derived from the CTS mouse in Japan. The animals are lean
and ketosis prone. They develop insulitis at approximately five weeks of age, and by seven …
and ketosis prone. They develop insulitis at approximately five weeks of age, and by seven …
Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.
…, FH Durie, RJ Noelle, JP Mordes… - Proceedings of the …, 1995 - National Acad Sciences
Combined treatment with allogeneic small lymphocytes or T-depleted small lymphocytes plus
a blocking antibody to CD40 ligand (CD40L) permitted indefinite pancreatic islet allograft …
a blocking antibody to CD40 ligand (CD40L) permitted indefinite pancreatic islet allograft …
Requirement of the JIP1 scaffold protein for stress-induced JNK activation
…, N Kelkar, TF Haydar, JP Mordes… - Genes & …, 2001 - genesdev.cshlp.org
The c-Jun N-terminal kinase (JNK) signal transduction pathway is activated in response to
the exposure of cells to environmental stress. Components of the JNK signaling pathway …
the exposure of cells to environmental stress. Components of the JNK signaling pathway …
Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4 (+) T cells, interferon-gamma, and …
…, RJ Noelle, LD Shultz, JP Mordes… - The Journal of …, 1998 - Am Soc Clin Investig
Treatment of C57BL/6 mice with one transfusion of BALB/c spleen cells and anti-CD154 (anti-CD40-ligand)
antibody permits BALB/c islet grafts to survive indefinitely and BALB/c skin …
antibody permits BALB/c islet grafts to survive indefinitely and BALB/c skin …
High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid …
RAM Hesselton, DL Greiner, JP Mordes… - Journal of Infectious …, 1995 - academic.oup.com
Inbred CB-17-scid/scid mice accept human peripheral blood mononuclear cell (PBMC)
xenografts and are susceptible to human immunodeficiency virus type 1 (HIV-1) infection, but low …
xenografts and are susceptible to human immunodeficiency virus type 1 (HIV-1) infection, but low …
Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in …
NN Iwakoshi, JP Mordes, TG Markees… - The Journal of …, 2000 - journals.aai.org
A two-element protocol consisting of one donor-specific transfusion (DST) plus a brief course
of anti-CD154 mAb greatly prolongs the survival of murine islet, skin, and cardiac allografts. …
of anti-CD154 mAb greatly prolongs the survival of murine islet, skin, and cardiac allografts. …
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment
…, Y Li, DL Greiner, XC Li, JP Mordes… - The Journal of …, 1999 - journals.aai.org
Sensitization to donor Ags is an enormous problem in clinical transplantation. In an islet
allograft model, presensitization of recipients through donor-specific transfusion (DST) 4 wk …
allograft model, presensitization of recipients through donor-specific transfusion (DST) 4 wk …
Animal models of diabetes
JP Mordes, AA Rossini - The American journal of medicine, 1981 - Elsevier
Spontaneous diabetes is a common occurrence in many animal species. In addition, animals
can be rendered diabetic by a wide variety of experimental procedures. Diabetic animals …
can be rendered diabetic by a wide variety of experimental procedures. Diabetic animals …