Many studies of chemopreventive drugs have suggested that their beneficial effects on
suppression of carcinogenesis and many other chronic diseases are mediated through activation …

Synthetic oleanane triterpenoids and rexinoids are two new classes of multifunctional drugs.
They are neither conventional cytotoxic agents, nor are they monofunctional drugs that …

We review the rationale for the use of synthetic oleanane triterpenoids (SOs) for prevention
and treatment of disease, as well as extensive biological data on this topic resulting from both …

A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of
cellular inflammatory processes such as the induction by IFN-γ of inducible nitric oxide …

Sepsis induced lethality is characterized by amplified host innate immune response. Nrf2, a
bZIP transcription factor, regulates a battery of cellular antioxidative genes and maintains …

We review the original rationale for the development and the chemistry of a series of new
synthetic oleanane triterpenoids (SO), based on oleanolic acid (1) as a starting material. Many …

Chronic obstructive pulmonary disease (COPD), which comprises emphysema and chronic
bronchitis resulting from prolonged exposure to cigarette smoke (CS), is a major public …

Purpose: Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible
for immune suppression in cancer. Therefore, it would be important to identify effective …

Synthetic triterpenoids have been developed, which are potent inducers of cytoprotective
enzymes and inhibitors of inflammation, greatly improving on the weak activity of naturally …

Loss of NF-E2-related factor 2 (Nrf2) signaling increases susceptibility to acute toxicity,
inflammation and carcinogenesis in mice due to the inability to mount adaptive responses. In …