On the mechanism of intestinal absorption of drugs

…, DJ Tocco, BB Brodie, LS Schanker - Journal of Pharmacology …, 1959 - ASPET
The intestinal absorption of acidic drugs is decreased severalfold and the absorption of
basic drugs increased severalfold when the pH of the intestinal contents is raised from 4 to 8. …
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Absorption of drugs from the rat small intestine

LS Schanker, DJ Tocco, BB Brodie… - Journal of Pharmacology …, 1958 - ASPET
The relative rates of absorption of a large number of drugs have been measured by perfusing
solutions of drugs through the entire small intestine of the anesthetized rat. A single …
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Absorption of drugs from the stomach. II. The human

CAM Hogben, LS Schanker, DJ Tocco… - Journal of pharmacology …, 1957 - ASPET
The human stomach is capable of absorbing most acidic drugs and the very weakly basic
drugs. Salicylic acid, aspirin, thiopental, secobarbital and antipyrine, which are undissociated …
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Mechanisms of drug absorption and distribution

LS Schanker - Annual Review of Pharmacology, 1961 - annualreviews.org
This interpretation of the distribution of drugs across the gastric mucosa is consistent with
the observations of a number of earlier workers that basic dyes, administered parenterally, …
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The importance of dissociation constant and lipid-solubility in influencing the passage of drugs into the cerebrospinal fluid

BB Brodie, H Kurz, LS Schanker - Journal of Pharmacology and …, 1960 - ASPET
Studies with 14 compounds indicate that the passage of drugs into cerebrospinal fluid (CSF)
is governed mainly by two physical properties: the degree of ionization of the drug; and the …
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Absorption of drugs from the stomach I. The rat

LS Schanker, PA Shore, BB Brodie… - Journal of Pharmacology …, 1957 - ASPET
When gastric contents are acid, the rat stomach rapidly absorbs most acidic drugs. In
contrast, all but the very weakest basic drugs are poorly absorbed. When gastric contents are …
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Absorption of aerosolized drugs from the rat lung.

RA Brown, LS Schanker - Drug metabolism and disposition, 1983 - ASPET
To investigate the absorption of aerosolized drugs from the rat lung, anesthetized animals
were allowed to inhale through a tracheal cannula liquid aerosols of drug solutions generated …
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Absorption of saccharides and urea from the rat lung

SJ Enna, LS Schanker - American Journal of Physiology …, 1972 - journals.physiology.org
… SCHANKER Department of Pharmacology, University of Missouri, Kansas Czly, Missouri
64110 … SCHANKER. Absorption of saccharides and urea from the rat lung. Am. …
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Absorption of drugs from the rat lung

SJ Enna, LS Schanker - American Journal of Physiology …, 1972 - journals.physiology.org
… SCHANKER Department of Pharmacology, University of Missouri, Kansas City, Missouri
64110 … AND LS SCHANKER … AND LS SCHANKER. Absorption …
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Species comparison of drug absorption from the lung after aerosol inhalation or intratracheal injection.

LS Schanker, EW Mitchell, RA Brown - Drug metabolism and disposition, 1986 - ASPET
To compare the rates of pulmonary absorption of aerosolized and intratracheally injected
drugs in the mouse, rabbit, and rat, anesthetized mice and rabbits prepared with a tracheal …
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