Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines
how this diagnosis should be established and how to recognize pseudoresistance. It …

Epilepsy and its treatment can have deleterious cognitive and behavioural consequences.
Affected individuals have a higher prevalence of neuropsychological dysfunction than the …

In the past decade, nine new drugs have been licensed for the treatment of epilepsy. With
limited clinical experience of these agents, the mechanisms of action of antiepileptic drugs …

To improve patient care and facilitate clinical research, the International League Against
Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant …

Background More than 30 percent of patients with epilepsy have inadequate control of seizures
with drug therapy, but why this happens and whether it can be predicted are unknown. …

The International League Against Epilepsy (ILAE) Commission on Classification and Terminology
has revised concepts, terminology, and approaches for classifying seizures and forms …

Objective: To delineate the temporal patterns of outcome and to determine the probability of
seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy. …

Importance A study published in 2000 showed that more than one-third of adults with epilepsy
have inadequate control of seizures with antiepileptic drugs (AEDs). This study evaluates …

Lamotrigine has been licensed widely as adjunctive therapy for partial and secondary
generalised seizures. Use of the drug as monotherapy was investigated in a double-blind, …

In a multicentre, double-blind trial 150 elderly patients (mean age 77 years) with newly
diagnosed epilepsy were randomised in a 2:1 ratio to treatment with lamotrigine (LTG) or …