The cardiovascular and other actions of angiotensin II (Ang II) are mediated by AT 1 and AT
2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. …

… Whitebread and M. de Gasparo, unpublished results). This suggests that CGP 42112 A
and PD 123177, although being specific ligands, have the ability to recognize slightly different …

The angiotensin AT 2 receptor subtype was recently cloned and pharmacologically
characterized but its function still remains elusive and controversial. It is a member of the G-protein …

… by EI Du Pont de Nemours (European patent … in the presence of 5 x lo-‘M CGP 421128
to block the A receptors … the tissues and cells used in this work, and Myriam de Gasparo for …

Materials and Methods Receptor binding studies.[3H] Aldosterone(49 Ci/mmol),[3H]
dexamethasone(43 Ci/mmol),[3Hjmethyltrienolone(87 Ci/mmol) and [3Hjprogesterone(57 Ci/mmol) …

… & DE GASPARO, M. (1992). The angiotensin AT2 receptor stimulates protein tyrosine
phosphatase … WHITEBREAD, S., MELE, M., KAMBER, B. & DE GASPARO, M. (1989). Preliminary …

Background To investigate the effect of angiotensin (Ang) II type 1 receptor (AT 1 ) blocker on
vascular remodeling and explore the possibility of the involvement of Ang II type 2 receptor …

… Marc de Gasparo Marc de Gasparo … ) with a linear gradient of 20-60% acetonitrile in a buffer
of 7% isopropanol, 0.25 M ammonium acetate, pH 5.0, at a flow rate of 1 ml/min. Carrier-free …

1. The disposition of valsartan, a potent angiotensin II receptor antagonist, was investigated
in six healthy male volunteers. They each received a single oral dose of80 mg of a C-…

Normal adults took a diet supplying at least 200 g carbohydrate per day for 3 days before
testing. On the test day a first group received 3 standard meals of different composition, …