Dendritic spine pathology in neuropsychiatric disorders

P Penzes, ME Cahill, KA Jones, JE VanLeeuwen… - Nature …, 2011 - nature.com
Substantial progress has been made toward understanding the genetic architecture,
cellular substrates, brain circuits and endophenotypic profiles of neuropsychiatric disorders, …

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
… , USA; Tel: +1 312 503 1174; Fax: +1 312 503 5101; E-mail: p-penzes@northwestern.edu …
[46] Bartos M, Vida I, Jonas P. Synaptic mechanisms of synchronized gamma oscillations in …

Dendritic structural plasticity and neuropsychiatric disease

MP Forrest, E Parnell, P Penzes - Nature Reviews Neuroscience, 2018 - nature.com
The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

…, NJ Brandon, A Kamiya, Z Yan, P Penzes… - Nature …, 2010 - nature.com
Synaptic spines are dynamic structures that regulate neuronal responsiveness and plasticity.
We examined the role of the schizophrenia risk factor DISC1 in the maintenance of spine …

[HTML][HTML] Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin

P Penzes, A Beeser, J Chernoff, MR Schiller, BA Eipper… - Neuron, 2003 - cell.com
… a dramatic increase in the number and size of clusters stained with the P-PAK antibody.
This effect was confirmed by Western analysis with the P-PAK antibody of extracts of 4-week-old …

[HTML][HTML] Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines

…, KM Woolfrey, CY Shum, DJ Surmeier, P Penzes - Neuron, 2007 - cell.com
Activity-dependent rapid structural and functional modifications of central excitatory synapses
contribute to synapse maturation, experience-dependent plasticity, and learning and …

[HTML][HTML] The neuronal Rho-GEF kalirin-7 interacts with PDZ domain–containing proteins and regulates dendritic morphogenesis

P Penzes, RC Johnson, R Sattler, X Zhang, RL Huganir… - Neuron, 2001 - cell.com
… The P2 fraction, further separated on a discontinuous sucrose gradient, was extracted in
0.5% Triton X-100 (1-Triton) and centrifuged to give supernatant (S) and pellet (P). Pellet P was …

The design of an asynchronous MIPS R3000 microprocessor

…, R Manohar, M Nystrom, P Penzes… - … Research in VLSI, 1997 - ieeexplore.ieee.org
… Since errors in the performance are, given P, reflected to the third power in thc Er2 figures,
we caution that Er2 figures really are only comparable between processors that do similar …

Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling

…, RT Strachan, BL Roth, P Penzes - Proceedings of the …, 2009 - National Acad Sciences
The 5-HT 2A serotonin receptor is the most abundant serotonin receptor subtype in the cortex
and is predominantly expressed in pyramidal neurons. The 5-HT 2A receptor is a target of …

Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity

…, LL Lash, GT Swanson, P Penzes - Proceedings of the …, 2008 - National Acad Sciences
Cortical information storage requires combined changes in connectivity and synaptic strength
between neurons, but the signaling mechanisms underlying this two-step wiring plasticity …