Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

SA Marchitti, C Brocker, D Stagos… - Expert opinion on drug …, 2008 - Taylor & Francis
Background: Aldehydes are highly reactive molecules. While several non-P450 enzyme
systems participate in their metabolism, one of the most important is the aldehyde …

Relationships of chemical concentrations in maternal and cord blood: a review of available data

…, SM Hays, CR Kirman, SA Marchitti… - Journal of Toxicology …, 2014 - Taylor & Francis
The developing fetus is likely to be exposed to the same environmental chemicals as the
mother during critical periods of growth and development. The degree of maternal–fetal transfer …

Environmental chemicals in breast milk and formula: exposure and risk assessment implications

…, MH Davis, EP Hines, SA Marchitti… - Environmental …, 2018 - ehp.niehs.nih.gov
Background: Human health risk assessment methods have advanced in recent years to more
accurately estimate risks associated with exposure during childhood. However, predicting …

Current breast milk PFAS levels in the United States and Canada: after all this time, why don't we know more?

…, H Goeden, DQ Naiman, SA Marchitti… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: Despite 20 y of biomonitoring studies of per- and polyfluoroalkyl substances (PFAS)
in both serum and urine, we have an extremely limited understanding of PFAS …

Ultraviolet radiation: cellular antioxidant response and the role of ocular aldehyde dehydrogenase enzymes

SA Marchitti, Y Chen, DC Thompson… - Eye & contact lens, 2011 - journals.lww.com
Solar ultraviolet radiation (UVR) exposes the human eye to near constant oxidative stress.
Evidence suggests that UVR is the most important environmental insult leading to the …

Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature

WJ Black, D Stagos, SA Marchitti… - Pharmacogenetics …, 2009 - journals.lww.com
Objective The human aldehyde dehydrogenase (ALDH) gene superfamily consists of 19
genes encoding enzymes critical for NAD (P)+-dependent oxidation of endogenous and …

Human and rat ABC transporter efflux of bisphenol a and bisphenol a glucuronide: interspecies comparison and implications for pharmacokinetic assessment

CS Mazur, SA Marchitti, M Dimova… - Toxicological …, 2012 - academic.oup.com
Significant interspecies differences exist between human and rodent with respect to
absorption, distribution, and excretion of bisphenol A (BPA) and its primary metabolite, BPA-…

Aldehyde dehydrogenase 3B1 (ALDH3B1): immunohistochemical tissue distribution and cellular-specific localization in normal and cancerous human tissues

SA Marchitti, DJ Orlicky, C Brocker… - … of Histochemistry & …, 2010 - journals.sagepub.com
… and does not crossreact with other ALDH isoforms (Marchitti et al. 2007b). Briefly, a …
Immunoblots demonstrating the efficacy of this antibody have been published (Marchitti et al…

Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress

SA Marchitti, C Brocker, DJ Orlicky, V Vasiliou - Free Radical Biology and …, 2010 - Elsevier
Aldehyde dehydrogenase (ALDH) enzymes are critical in the detoxification of aldehydes.
The human genome contains 19 ALDH genes, mutations in which are the basis of several …