Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP
NMDA receptor (NMDAR)-mediated excitotoxicity plays an important role in several CNS
disorders, including epilepsy, stroke, and ischemia. Here we demonstrate the involvement of …
disorders, including epilepsy, stroke, and ischemia. Here we demonstrate the involvement of …
Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices
SM Goebel-Goody, KD Davies, RMA Linger… - Neuroscience, 2009 - Elsevier
Recent evidence demonstrates that N-methyl-d-aspartate receptor (NMDAR) trafficking
contributes to synaptic plasticity in the hippocampus. Phosphorylation of tyrosine residues, …
contributes to synaptic plasticity in the hippocampus. Phosphorylation of tyrosine residues, …
Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders
SM Goebel-Goody, M Baum, CD Paspalas… - Pharmacological …, 2012 - ASPET
Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific phosphatase that
modulates key signaling molecules involved in synaptic plasticity and neuronal function. …
modulates key signaling molecules involved in synaptic plasticity and neuronal function. …
Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model
SM Goebel‐Goody, ED Wilson‐Wallis… - Genes, Brain and …, 2012 - Wiley Online Library
Fragile X syndrome (FXS), the most common inherited form of intellectual disability and
prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that …
prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that …
[HTML][HTML] The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications
Glutamatergic signaling through N-methyl-D-aspartate receptors (NMDARs) is required for
synaptic plasticity. Disruptions in glutamatergic signaling are proposed to contribute to the …
synaptic plasticity. Disruptions in glutamatergic signaling are proposed to contribute to the …
Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase
…, RK Freund, SM Goebel-Goody… - Proceedings of the …, 2011 - National Acad Sciences
… Immunoprecipitation and immunoblotting were performed as described in Goebel-Goody et
al. (55). A five-point standard curve of a hippocampal homogenate was included on each gel …
al. (55). A five-point standard curve of a hippocampal homogenate was included on each gel …
Major vault protein is expressed along the nucleus–neurite axis and associates with mRNAs in cortical neurons
…, DV Venkitaramani, SM Goebel-Goody… - Cerebral …, 2009 - academic.oup.com
Major Vault Protein (MVP), the main constituent of the vault ribonucleoprotein particle, is
highly conserved in eukaryotic cells and upregulated in a variety of tumors. Vaults have been …
highly conserved in eukaryotic cells and upregulated in a variety of tumors. Vaults have been …
[HTML][HTML] Long term synaptic depression that is associated with GluR1 dephosphorylation but not α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) …
KD Davies, SM Goebel-Goody, SJ Coultrap… - Journal of biological …, 2008 - ASBMB
Long lasting changes in the strength of synaptic transmission in the hippocampus are thought
to underlie certain forms of learning and memory. Accordingly, the molecular mechanisms …
to underlie certain forms of learning and memory. Accordingly, the molecular mechanisms …
Taking STEPs forward to understand fragile X syndrome
SM Goebel-Goody, PJ Lombroso - Modeling Fragile X Syndrome, 2012 - Springer
… Recent work demonstrates that the concentration of STEP 61 is higher in extrasynaptic
membranes than synaptic membranes (Goebel-Goody et al. 2009). Given that clathrin-mediated …
membranes than synaptic membranes (Goebel-Goody et al. 2009). Given that clathrin-mediated …
[CITATION][C] PJ Lombroso Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders., 2012, 64
SM Goebel-Goody, M Baum, CD Paspalas… - DOI: https://doi. org/10.1124/pr