Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP

J Xu, P Kurup, Y Zhang, SM Goebel-Goody… - Journal of …, 2009 - Soc Neuroscience
NMDA receptor (NMDAR)-mediated excitotoxicity plays an important role in several CNS
disorders, including epilepsy, stroke, and ischemia. Here we demonstrate the involvement of …

Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices

SM Goebel-Goody, KD Davies, RMA Linger… - Neuroscience, 2009 - Elsevier
Recent evidence demonstrates that N-methyl-d-aspartate receptor (NMDAR) trafficking
contributes to synaptic plasticity in the hippocampus. Phosphorylation of tyrosine residues, …

Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders

SM Goebel-Goody, M Baum, CD Paspalas… - Pharmacological …, 2012 - ASPET
Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific phosphatase that
modulates key signaling molecules involved in synaptic plasticity and neuronal function. …

Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model

SM GoebelGoody, ED Wilson‐Wallis… - Genes, Brain and …, 2012 - Wiley Online Library
Fragile X syndrome (FXS), the most common inherited form of intellectual disability and
prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that …

[HTML][HTML] The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications

…, J Xu, P Kurup, J Brouillette, SM Goebel-Goody… - Translational …, 2012 - nature.com
Glutamatergic signaling through N-methyl-D-aspartate receptors (NMDARs) is required for
synaptic plasticity. Disruptions in glutamatergic signaling are proposed to contribute to the …

Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase

…, RK Freund, SM Goebel-Goody… - Proceedings of the …, 2011 - National Acad Sciences
… Immunoprecipitation and immunoblotting were performed as described in Goebel-Goody et
al. (55). A five-point standard curve of a hippocampal homogenate was included on each gel …

Major vault protein is expressed along the nucleus–neurite axis and associates with mRNAs in cortical neurons

…, DV Venkitaramani, SM Goebel-Goody… - Cerebral …, 2009 - academic.oup.com
Major Vault Protein (MVP), the main constituent of the vault ribonucleoprotein particle, is
highly conserved in eukaryotic cells and upregulated in a variety of tumors. Vaults have been …

[HTML][HTML] Long term synaptic depression that is associated with GluR1 dephosphorylation but not α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) …

KD Davies, SM Goebel-Goody, SJ Coultrap… - Journal of biological …, 2008 - ASBMB
Long lasting changes in the strength of synaptic transmission in the hippocampus are thought
to underlie certain forms of learning and memory. Accordingly, the molecular mechanisms …

Taking STEPs forward to understand fragile X syndrome

SM Goebel-Goody, PJ Lombroso - Modeling Fragile X Syndrome, 2012 - Springer
… Recent work demonstrates that the concentration of STEP 61 is higher in extrasynaptic
membranes than synaptic membranes (Goebel-Goody et al. 2009). Given that clathrin-mediated …

[CITATION][C] PJ Lombroso Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders., 2012, 64

SM Goebel-Goody, M Baum, CD Paspalas… - DOI: https://doi. org/10.1124/pr