Prostanoid receptors: structures, properties, and functions

S Narumiya, Y Sugimoto… - Physiological reviews, 1999 - journals.physiology.org
… Prostaglandin G, PGH, PGI, and TxA are chemically unstable and are degraded into inactive
products under physiological conditions, with a half-life of 30 s to a few minutes. Other PG, …

[HTML][HTML] Prostaglandin E receptors

Y Sugimoto, S Narumiya - Journal of Biological Chemistry, 2007 - ASBMB
… The EP2 and EP4 receptors couple to G s and mediate increases in cAMP concentrations.
The major signaling pathway of the EP3 receptor is inhibition of adenylate cyclase via G i . It …

[HTML][HTML] Genetic and pharmacological analysis of prostanoid receptor function

S Narumiya, GA FitzGerald - The Journal of clinical …, 2001 - Am Soc Clin Investig
… Thus, while PGI 2 analogs ligate the IP and activate adenylate cyclase via G s in a dose-dependent
manner, higher concentrations of the ligand couple the IP to phospholipase C …

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32. 1

…, M Nishimura, I Akiguchi, J Kimura, S Narumiya… - Nature …, 1994 - nature.com
We have identified a novel gene containing CAG repeats and mapped it to chromosome
14q32.1, the genetic locus for Machado-Joseph disease (MJD). In normal individuals the gene …

Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent …

…, US Schwarz, T Ishizaki, S Narumiya… - The Journal of cell …, 2001 - rupress.org
The transition of cell–matrix adhesions from the initial punctate focal complexes into the
mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, …

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

…, T Obinata, K Ohashi, K Mizuno, S Narumiya - Science, 1999 - science.org
The actin cytoskeleton undergoes extensive remodeling during cell morphogenesis and
motility. The small guanosine triphosphatase Rho regulates such remodeling, but the …

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

…, K Yamagami, J Inui, M Maekawa, S Narumiya - Nature, 1997 - nature.com
Abnormal smooth-muscle contractility may be a major cause of disease states such as
hypertension, and a smooth-muscle relaxant that modulates this process would be useful …

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

…, Y Mori, H Takeshima, S Narumiya, S Numa - Nature, 1989 - nature.com
… The inward currents were elicited by a 1.0 s pulse stepped from a holding potential of –50
mV to +10 mV before (upper trace) and during exposure to 5 pM BAY K8644 (lower trace). The …

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases

…, J Keel, K Nonomura, M Maekawa, S Narumiya - Molecular …, 2000 - ASPET
… Y-27632 abolished stress fibers in Swiss 3T3 cells at 10 μM, but the G 1 -S phase transition
… and it caused significant delay in the G 1 -S transition and inhibition of cytokinesis at 10 μM. …

Cloning and expression of cDNA for a human thromboxane A2 receptor

…, Y Yokota, R Kageyama, S Nakanishi, S Narumiya - Nature, 1991 - nature.com
… antagonists S-145 and ONO-3708 competed for the [3H]S-145 binding with an order of
potency identical to that observed with the TXA2 receptor in other cells3,4,!6,17. Other …