User profiles for S. Prömel

Simone Prömel

Institute of Cell Biology, Heinrich Heine University Düsseldorf
Verified email at uni-duesseldorf.de
Cited by 2235

International union of basic and clinical pharmacology. xciv. adhesion g protein–coupled receptors

…, KR Monk, MC Peeters, X Piao, S Prömel… - Pharmacological …, 2015 - ASPET
The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

…, G Kaur, L Lambert, OA Leach, S Prömel… - Nature, 2012 - nature.com
… 293T cells (ATCC) using the RNeasy Micro Kit (Qiagen) and cDNA was synthesized using
the High Capacity RNA-to-cDNA Kit (Applied Biosystems), according to the manufacturer’s

Matching structure with function: the GAIN domain of adhesion-GPCR and PKD1-like proteins

S Prömel, T Langenhan, D Araç - Trends in pharmacological sciences, 2013 - cell.com
… In most GAIN domains, the cleavage site is HL↓T/S. Autoproteolysis can occur only if the
residue at position +1 is a threonine, serine, or cysteine. However, the residues at positions –2 …

A guide to adhesion GPCR research

…, K Spiess, K Trajković, M Kosloff, S Prömel - The FEBS …, 2022 - Wiley Online Library
Adhesion G protein‐coupled receptors (aGPCRs) are a class of structurally and functionally
highly intriguing cell surface receptors with essential functions in health and disease. Thus, …

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

…, M Sauer, E Asan, S Rothemund, J Winkler, S Prömel… - Elife, 2017 - elifesciences.org
… We sought to test this hypothesis by relaxing dCIRL’s extracellular region via gradual elongation
of … We therefore hypothesize that ECD length and tensile properties may adjust dCIRL’s

[HTML][HTML] Activation of adhesion G protein-coupled receptors: agonist specificity of Stachel sequence-derived peptides

…, S Rothemund, T Schöneberg, S Prömel… - Journal of Biological …, 2017 - ASBMB
… ) couple G q/11 proteins and GPR110 also couples to the G s protein (see below).
Therefore, we used a cAMP formation assay (G s ), NFAT (the activation of the nuclear factor of …

[HTML][HTML] Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1

…, C Hennig, T Schöneberg, S Prömel - PLoS …, 2015 - journals.plos.org
… G s protein signal we verified that the LAT-1-mediated elevation of cAMP levels was due to
G s -… Therefore, we conclude that LAT-1 very likely activates the G s protein/adenylyl cyclase …

[HTML][HTML] The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse

H Waller-Evans, S Prömel, T Langenhan, J Dixon… - PloS one, 2010 - journals.plos.org
… The genomes of the sea urchin S. purpuratus and of Trichoplax adherens are predicted to
encode Adhesion-GPCRs with N-termini containing a CUB domain in conjunction with EGF or …

[PDF][PDF] Involvement of the adhesion GPCRs latrophilins in the regulation of insulin release

…, R Kraft, S Rothemund, T Schöneberg, S Prömel - Cell reports, 2019 - cell.com
… This exon encodes a part of the receptor’s seven transmembrane region and its lack shortens
the third intracellular loop (Figure 1D). These splice variants are of great interest because …

Characterization and functional study of a cluster of four highly conserved orphan adhesion‐GPCR in mouse

S Prömel, H Waller‐Evans, J Dixon… - Developmental …, 2012 - Wiley Online Library
… Additionally, Gpr110 and Gpr116 encode a SEA (sea urchin sperm protein/enterokinase/agrin)
domain in their predicted ectodomains, and GPR116 exhibits two additional …