The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

TA Esbenshade, KE Browman… - British journal of …, 2008 - Wiley Online Library
The histamine H 3 receptor, first described in 1983 as a histamine autoreceptor and later
shown to also function as a heteroreceptor that regulates the release of other neurotransmitters, …

Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl] ethyl}-benzofuran-5-yl) benzonitrile]: II. Neurophysiological characterization and broad …

GB Fox, TA Esbenshade, JB Pan, RJ Radek… - … of Pharmacology and …, 2005 - ASPET
Acute pharmacological blockade of central histamine H 3 receptors (H 3 Rs) enhances
arousal/attention in rodents. However, there is little information available for other behavioral …

Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease

JD Brioni, TA Esbenshade, TR Garrison… - … of Pharmacology and …, 2011 - ASPET
H 3 antagonists increase the release of brain histamine, acetylcholine, noradrenaline, and
dopamine, neurotransmitters that are known to modulate cognitive processes. The ability to …

Localization of histamine H4 receptors in the central nervous system of human and rat

…, AL Nikkel, AM Manelli, GC Hsieh, TA Esbenshade… - Brain research, 2009 - Elsevier
Existing data on the expression of H 4 histamine receptor in the CNS are conflicting and
inconclusive. In this report, we present the results of experiments that were conducted in order to …

[HTML][HTML] Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders

TA Esbenshade, GB Fox, MD Cowart - Molecular interventions, 2006 - triggered.clockss.org
The histamine H 3 receptor is an attractive G protein–coupled receptor drug target that
regulates neurotransmission in the central nervous system and plays a role in cognitive and …

Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes.

…, TL Theroux, S Hollinger, C Han, TA Esbenshade - Molecular …, 1994 - ASPET
The potencies and intrinsic activities of agonists in activating cloned alpha 1-adrenergic
receptor (AR) subtypes were compared. The hamster alpha 1B-, bovine alpha 1C-, or rat alpha …

Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup

GB Fox, JB Pan, TA Esbenshade, YL Bennani… - Behavioural brain …, 2002 - Elsevier
Histamine H 3 receptor antagonists have been proposed as potentially useful therapeutic
agents for the treatment of several disorders including attention deficit, schizophrenia, …

4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition …

…, KC Marsh, JP Sullivan, TA Esbenshade… - Journal of medicinal …, 2005 - ACS Publications
H 3 receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered,
which are potent in vitro at human and rat H 3 receptors, with K i values of 0.1−5.8 nM. …

[HTML][HTML] α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles

…, D Baglietto-Vargas, KN Green, TA Esbenshade… - The American journal of …, 2014 - Elsevier
Alzheimer disease (AD) is a progressive neurodegenerative disorder with associated
memory loss, spatial disorientation, and other psychiatric problems. Cholinergic system …

H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

…, AA Hancock, MD Cowart, TA Esbenshade… - Pharmacology …, 2010 - Elsevier
The histamine H 4 receptor (H 4 R) is expressed primarily on cells involved in inflammation
and immune responses. To determine the potential role of H 4 R in pain transmission, the …