The centrifugal microfluidic platform has been a focus of academic and industrial research
efforts for almost 40 years. Primarily targeting biomedical applications, a range of assays have …

How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains
unanswered today. Early biochemical and microscopic studies revealed the existence of …

This review evaluates hydrogel-forming polymers that are suitable for soft tissue
engineering with a focus on materials that can be fabricated using additive manufacturing (3D-printing). …

The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate these …

We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…

CTCF and the associated cohesin complex play a central role in insulator function and
higher-order chromatin organization of mammalian genomes. Recent studies identified a …

The incomplete identification of structural variants (SVs) from whole-genome sequencing
data limits studies of human genetic diversity and disease association. Here, we apply a suite …

The frequency of ventricular premature complexes and the degree of impairment of left
ventricular ejection fraction are major predictors of cardiac mortality and sudden death in the year …

Background The objective of this randomized clinical trial of elective coronary artery bypass
grafting was to investigate whether intraoperative mean arterial pressure below …

Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding 1 . Translating these risk variants into mechanistic …