Abstract
9-β-D-Arabinofuranosyladenine was given to two patients by relatively rapid (½, 2 hr) intravenous infusion, to two patients as a continuous intravenous drip over 24 hr, and to two patients as an intramuscular suspension. Blood plasma levels and urinary excretion of ara-A1 and the chief metabolic product. 9-β-D-arabinofuranosylhypoxanthine, were measured at intervals up to 24 hr. Rapid intravenous infusions resulted in 88 and 97% recoveries in urine by 24 hr, as ara-H and ara-A. Urinary excretion after administration as a continuous intravenous drip was 33 and 41%, respectively, in the first 24 hr. The two patients receiving intramuscular injection excreted only 1.7 and 7.1% of the dose, respectively, in 24 hr. The latter finding would indicate poor absorption of an intramuscular dose.
Footnotes
- Received May 29, 1973.
- Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics