Abstract
An enzyme that transfers the methyl group of S-adenosylmethionine to the amino group of serotonin has been described. It has been partially purified and its properties studied. The serotonin methylating enzyme can N-methylate a variety of normally occurring compounds such as dopamine, normetanephrine, metanephrine, epinephrine, tyramine, and octopamine as well as a variety of foreign compounds such as ephedrine, amphetamine, aniline, normorphine, normeperidine and nornicotine. The enzyme is highly localized in the rabbit lung.
Footnotes
- Received June 28, 1962.