Abstract
The fate of norepinephrine-H3 released from binding sites by the action of reserpine and tyramine has been examined. As a result of tyramine administration the bound catecholamines are released directly into the circulation; a small portion is metabolized in the tissue prior to release, and this, predominantly by O-methylation. Reserpine, on the other hand, depletes tissue of the catecholamine by metabolism within the tissue, predominantly by deamination; little norepinephrine is released into an active form. These results are discussed in relation to the metabolic fate of the bound pools of norepinephrine.
Footnotes
- Received August 20, 1962.