Table of Contents

Review Articles

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  Evaluation of the “Pipeline” for Development of Medications for Cocaine Use Disorder: A Review of Translational Preclinical, Human Laboratory, and Clinical Trial Research

  Paul W. Czoty, William W. Stoops and Craig R. Rush

  Michael A. Nader, ASSOCIATE EDITOR, Wake Forest School of Medicine, Winston-Salem, North Carolina (P.W.C.); and University of Kentucky, Lexington, Kentucky (W.W.S., C.R.R.)

  Pharmacological Reviews July 2016, 68 (3) 533-562; DOI: https://doi.org/10.1124/pr.115.011668
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  Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review

  Martin J. Brodie, Frank Besag, Alan B. Ettinger, Marco Mula, Gabriella Gobbi, Stefano Comai, Albert P. Aldenkamp and Bernhard J. Steinhoff

  David R. Sibley, ASSOCIATE EDITOR, Epilepsy Unit, West Glasgow Ambulatory Care Hospital–Yorkhill, Glasgow, Scotland (M.J.B.); East London National Health Service Foundation Trust, Bedford, United Kingdom (F.B.); University College London School of Pharmacy, London, United Kingdom (F.B.); Winthrop University Hospital, Mineola, New York (A.B.E.); Epilepsy Group, Atkinson Morley Regional Neuroscience Centre, St. George’s University Hospitals National Health Service Foundation Trust, London, United Kingdom (M.M.); Institute of Medical and Biomedical Sciences, St. George’s, University of London, London, United Kingdom (M.M.); Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Quebec, Canada (G.G., S.C.); McGill University Health Center, McGill University, Montreal, Quebec, Canada (G.G., S.C.); Division of Neuroscience, San Raffaele Scientific Institute and Vita-Salute University, Milan, Italy (S.C.); Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands (A.P.A.); Maastricht University Medical Centre, Maastricht, The Netherlands (A.P.A.); and Kork Epilepsy Centre, Kehl-Kork, Germany (B.J.S.)

  Pharmacological Reviews July 2016, 68 (3) 563-602; DOI: https://doi.org/10.1124/pr.115.012021
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  Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease

  Brice Korkmaz, Adam Lesner, Carla Guarino, Magdalena Wysocka, Christine Kellenberger, Hervé Watier, Ulrich Specks, Francis Gauthier and Dieter E. Jenne

  David R. Sibley, ASSOCIATE EDITOR, INSERM U-1100, Centre d’Etude des Pathologies Respiratoires and Université François Rabelais, Tours, France (B.K., C.G., F.G.); Faculty of Chemistry, University of Gdansk, Gdansk, Poland (A.L., M.W.); Architecture et Fonction des Macromolécules Biologiques, Unité Mixte de Recherche 7257, Marseille, France (C.K.); Génétique, Immunothérapie, Chimie et Cancer, Unité Mixte de Recherche 7292, Université François Rabelais, Tours, France (H.W.); Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic and Foundation, Rochester, Minnesota (U.S.); Comprehensive Pneumology Center, Institute of Lung Biology and Disease, German Center for Lung Research, Munich, Germany (D.E.J.); and Max Planck Institute of Neurobiology, Planegg-Martinsried, Germany (D.E.J.)

  Pharmacological Reviews July 2016, 68 (3) 603-630; DOI: https://doi.org/10.1124/pr.115.012104
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  Molecular Pharmacology of δ-Opioid Receptors

  Louis Gendron, Catherine M. Cahill, Mark von Zastrow, Peter W. Schiller and Graciela Pineyro

  Christie J. Macdonald, ASSOCIATE EDITOR, Département de Pharmacologie-Physiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Centre de Recherche du CHU de Sherbrooke, Centre d’excellence en neurosciences de l’Univeristé de Sherbrooke, and Institut de Pharmacologie de Sherbrooke, Sherbrooke, Quebec, Canada (L.G.); Québec Pain Research Network, Sherbrooke, Quebec, Canada (L.G.); Departments of Anesthesiology and Perioperative Care and Pharmacology, University of California, Irvine, California (C.M.C.); Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada (C.M.C.); Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, California (M.v.Z.); Laboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montréal, Montreal, Quebec, Canada (P.W.S.); and Departments of Psychiatry, Pharmacology, and Neurosciences, Faculty of Medicine, University of Montréal and Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada (G.P.)

  Pharmacological Reviews July 2016, 68 (3) 631-700; DOI: https://doi.org/10.1124/pr.114.008979
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  Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

  Phatsapong Yingchoncharoen, Danuta S. Kalinowski and Des R. Richardson

  Eric L. Barker, ASSOCIATE EDITOR, Molecular Pharmacology and Pathology Program, Department of Pathology, Faculty of Medicine, Bosch Institute, The University of Sydney, Sydney, NSW, Australia

  Pharmacological Reviews July 2016, 68 (3) 701-787; DOI: https://doi.org/10.1124/pr.115.012070
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  Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease

  Peter J. Barnes

  Clive Page, ASSOCIATE EDITOR, National Heart and Lung Institute, Imperial College, London, United Kingdom

  Pharmacological Reviews July 2016, 68 (3) 788-815; DOI: https://doi.org/10.1124/pr.116.012518
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  The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

  M. D. Scofield, J. A. Heinsbroek, C. D. Gipson, Y. M. Kupchik, S. Spencer, A. C. W. Smith, D. Roberts-Wolfe and P. W. Kalivas

  Jeffrey M. Witkin, ASSOCIATE EDITOR, Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina (M.D.S., J.A.H., S.S., D.R.-W., P.W.K.); Department of Psychology, Arizona State University, Tempe, Arizona (C.D.G.); Department of Neuroscience, Hebrew University, Jerusalem, Israel (Y.M.K.); and Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York (A.C.W.S.)

  Pharmacological Reviews July 2016, 68 (3) 816-871; DOI: https://doi.org/10.1124/pr.116.012484
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  Manipulating Angiogenesis by Targeting Endothelial Metabolism: Hitting the Engine Rather than the Drivers—A New Perspective?

  Lucas Treps, Lena-Christin Conradi, Ulrike Harjes and Peter Carmeliet

  Yoshihiro Ishikawa, ASSOCIATE EDITOR, Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, and Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Leuven, Belgium

  Pharmacological Reviews July 2016, 68 (3) 872-887; DOI: https://doi.org/10.1124/pr.116.012492