1.1 |
Superfamily of Cys-loop receptors |
| (Cockcroft et al., 1990;Karlin and Akabas, 1995) Includes ion channels gated by GABA, glycine, 5-HT, acetylcholine (nicotinic), and glutamate (anion channel) (Nistri and Arenson, 1983; Cully et al., 1994,1996) | 1.1 1.1 1.1 1.1 1.1 | GABA GLY GLU ACH 5HT |
1.2 |
Glutamate-gated cation channels |
| Includes NMDA and non-NMDA receptors | 1.2 | GLU |
1.3 |
Related to voltage-gated cation channels |
| Includes receptors for cyclic nucleotides and for IP3 as well as the “ryanodine receptor”3-a
| 1.3 | IP3 |
1.4 |
Related to epithelial Na+ channels; non-peptide–gated
|
| Includes P2X receptors for ATP (North and Barnard, 1997) and proton-gated cation channels (Waldmann et al., 1997) | 1.4 | NUCT |
1.5 |
Related to epithelial Na+channels; peptide-gated |
| e.g., FMRF-gated Na+channel (Lingueglia et al., 1995) | 1.5 | FMRF |
1.63-b
|
Related to inward rectifier K+channels |
| e.g., ATP-activated K+ channel (Lesageet al., 1995; Takumi et al., 1995) and the ATP-antagonized K+ channel (K
ATP) (Clement et al., 1997; Gribble et al., 1997;Tucker et al., 1997)3-c
| 1.6 | NUCT |
1.73-b
|
Related to ATPase-linked transporters
|
| e.g., CFTR (ATP-activated anion channel) (Baukrowvitz et al., 1994)3-d
| 1.7 | NUCT |
1.83-b
|
Related to neurotransmitter transporters
|
| e.g., glutamate-activated chloride channel/EAA transporter (Fairman et al., 1995; Picaud et al., 1995)3-d
| 1.8 | GLU |