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Review ArticleReview

Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized?

Jiunn H. Lin, Masato Chiba and Thomas A. Baillie
Pharmacological Reviews June 1999, 51 (2) 135-158;
Jiunn H. Lin
Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania
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Masato Chiba
Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania
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Thomas A. Baillie
Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania
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Article Information

vol. 51 no. 2 135-158
PubMed 
10353984

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online June 1, 1999.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jiunn H. Lin1,
  2. Masato Chiba, and
  3. Thomas A. Baillie
  1. Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania

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Pharmacological Reviews: 51 (2)
Pharmacological Reviews
Vol. 51, Issue 2
1 Jun 1999
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Review ArticleReview

Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized?

Jiunn H. Lin, Masato Chiba and Thomas A. Baillie
Pharmacological Reviews June 1, 1999, 51 (2) 135-158;

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Review ArticleReview

Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized?

Jiunn H. Lin, Masato Chiba and Thomas A. Baillie
Pharmacological Reviews June 1, 1999, 51 (2) 135-158;
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  • Article
    • I. Introduction
    • II. Physiological and Biochemical Factors Affecting Intestinal Metabolism
    • III. Drug Absorption and Intestinal First-Pass Metabolism
    • IV. Relative Contribution of Hepatic and Intestinal First-Pass Metabolism
    • V. Conceptions and Misconceptions
    • VI. Conclusions
    • Acknowledgment
    • Footnotes
    • Abbreviations
    • References
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