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Review ArticleReview

Vanilloid (Capsaicin) Receptors and Mechanisms

Arpad Szallasi and Peter M. Blumberg
Pharmacological Reviews June 1999, 51 (2) 159-212;
Arpad Szallasi
Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland
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Peter M. Blumberg
Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland
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Article Information

vol. 51 no. 2 159-212
PubMed 
10353985

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online June 1, 1999.

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The American Society for Pharmacology and Experimental Therapeutics

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Pharmacological Reviews: 51 (2)
Pharmacological Reviews
Vol. 51, Issue 2
1 Jun 1999
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Review ArticleReview

Vanilloid (Capsaicin) Receptors and Mechanisms

Arpad Szallasi and Peter M. Blumberg
Pharmacological Reviews June 1, 1999, 51 (2) 159-212;

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Review ArticleReview

Vanilloid (Capsaicin) Receptors and Mechanisms

Arpad Szallasi and Peter M. Blumberg
Pharmacological Reviews June 1, 1999, 51 (2) 159-212;
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  • Article
    • I. Foreword: A Brief History of a Really “Hot” Aspect of Pharmacology
    • II. Introduction
    • III. Direct Evidence for a Vanilloid (Capsaicin) Receptor
    • IV. Anatomical Localization and Tissue Specificity of VRs
    • V. Evidence for Multiple VRs
    • VI. Biochemical Pharmacology of VRs
    • VII. Requirements for Ligand Recognition by VRs: Typical and Novel Vanilloids
    • VIII. Vanilloid Mechanisms
    • IX. Diverse Biological Actions of Vanilloids; VR-Mediated and Independent Mechanism
    • X. Species-Related Differences in Vanilloid Actions
    • XI. Endogenous Vanilloids: Do They Exist?
    • XII. Vanilloids in Clinical Practice: Current Uses and Future Perspectives
    • XIII. Vanilloids: Carcinogens, Anticarcinogens, or Neither?
    • XIV. Concluding Remarks, Emerging Principles, and Future Perspectives
    • Acknowledgments
    • Appendix
    • Note Added in Proof.
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
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