Cover Caption
About the cover: Schematic view of the catalytic site of COMT demonstrating the necessary amino acids (rectangular boxes), Mg2+, and water molecule, with AdoMet and the catechol substrate. Among the amino acids, there are "gatekeepers" and catalytic amino acids, notably Lys144, which acts as a general catalytic base. The activated hydroxyl, to be methylated, is shown in bold. See the article by Männistö on page 593 of this issue.
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