Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Pharmacological Reviews
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Pharmacological Reviews

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit Pharm Rev on Facebook
  • Follow Pharm Rev on Twitter
  • Follow ASPET on LinkedIn
Review ArticleReview

International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors

Philip M. Murphy, Marco Baggiolini, Israel F. Charo, Caroline A. Hébert, Richard Horuk, Kouji Matsushima, Louis H. Miller, Joost J. Oppenheim and Christine A. Power
Pharmacological Reviews March 2000, 52 (1) 145-176;
Philip M. Murphy
1 2 3 4 5 6 7 8 9
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marco Baggiolini
1 2 3 4 5 6 7 8 9
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Israel F. Charo
1 2 3 4 5 6 7 8 9
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Caroline A. Hébert
1 2 3 4 5 6 7 8 9
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richard Horuk
1 2 3 4 5 6 7 8 9
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kouji Matsushima
1 2 3 4 5 6 7 8 9
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Louis H. Miller
1 2 3 4 5 6 7 8 9
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joost J. Oppenheim
1 2 3 4 5 6 7 8 9
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christine A. Power
1 2 3 4 5 6 7 8 9
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Chemokine receptors comprise a large family of seven transmembrane domain G protein-coupled receptors differentially expressed in diverse cell types. Biological activities have been most clearly defined in leukocytes, where chemokines coordinate development, differentiation, anatomic distribution, trafficking, and effector functions and thereby regulate innate and adaptive immune responses. Pharmacological analysis of chemokine receptors is at an early stage of development. Disease indications have been established in human immunodeficiency virus/acquired immune deficiency syndrome and in Plasmodium vivax malaria, due to exploitation of CCR5 and Duffy, respectively, by the pathogen for cell entry. Additional indications are emerging among inflammatory and immunologically mediated diseases, but selection of targets in this area still remains somewhat speculative. Small molecule antagonists with nanomolar affinity have been reported for 7 of the 18 known chemokine receptors but have not yet been studied in clinical trials. Virally encoded chemokine receptors, as well as chemokine agonists and antagonists, and chemokine scavengers have been identified in medically important poxviruses and herpesviruses, again underscoring the importance of the chemokine system in microbial pathogenesis and possibly identifying specific strategies for modulating chemokine action therapeutically. The purpose of this review is to update current concepts of the biology and pharmacology of the chemokine system, to summarize key information about each chemokine receptor, and to describe a widely accepted receptor nomenclature system, ratified by the International Union of Pharmacology, that is facilitating clear communication in this area.

Footnotes

  • ↵1 Address for correspondence: Dr. Philip M. Murphy, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N113, Bethesda, MD 20892. E-mail: pmm{at}nih.gov

  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text
PreviousNext
Back to top

In this issue

Pharmacological Reviews: 52 (1)
Pharmacological Reviews
Vol. 52, Issue 1
1 Mar 2000
  • Table of Contents
  • About the Cover
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Pharmacological Reviews article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
(Your Name) has forwarded a page to you from Pharmacological Reviews
(Your Name) thought you would be interested in this article in Pharmacological Reviews.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Review ArticleReview

International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors

Philip M. Murphy, Marco Baggiolini, Israel F. Charo, Caroline A. Hébert, Richard Horuk, Kouji Matsushima, Louis H. Miller, Joost J. Oppenheim and Christine A. Power
Pharmacological Reviews March 1, 2000, 52 (1) 145-176;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Review ArticleReview

International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors

Philip M. Murphy, Marco Baggiolini, Israel F. Charo, Caroline A. Hébert, Richard Horuk, Kouji Matsushima, Louis H. Miller, Joost J. Oppenheim and Christine A. Power
Pharmacological Reviews March 1, 2000, 52 (1) 145-176;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • I. Overview
    • II. Introduction
    • III. CXC Chemokine Receptor Subtypes
    • IV. CC Chemokine Receptor Subtypes
    • V. CX3C Chemokine Receptor Subtypes
    • VI. Chemokine Receptor Subtypes
    • VII. Chemokine Binding Proteins
    • VIII. Virus-Encoded Chemokine Receptors
    • IX. Conclusions
    • Acknowledgments
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • RNA Interference in Biology and Medicine
  • Induction of Drug Metabolism: The Role of Nuclear Receptors
  • International Union of Pharmacology. XXXIX. Compendium of Voltage-Gated Ion Channels: Sodium Channels
Show more REVIEW

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Pharmacological Reviews
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacology Research & Perspectives
ISSN 1521-0081 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics