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Review ArticleReview

The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer

Elliott Middleton Jr., Chithan Kandaswami and Theoharis C. Theoharides
Pharmacological Reviews December 2000, 52 (4) 673-751;
Elliott Middleton Jr.
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Chithan Kandaswami
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Theoharis C. Theoharides
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Article Information

vol. 52 no. 4 673-751

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online December 1, 2000.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Elliott Middleton Jr.†,1,
  2. Chithan Kandaswami1, and
  3. Theoharis C. Theoharides1,2
  1. 1Chebeague Island Institute of Natural Product Research, Chebeague Island, Maryland (E.M., C.K.); and 2Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts (T.C.T.)
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Pharmacological Reviews: 52 (4)
Pharmacological Reviews
Vol. 52, Issue 4
1 Dec 2000
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Review ArticleReview

The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer

Elliott Middleton, Chithan Kandaswami and Theoharis C. Theoharides
Pharmacological Reviews December 1, 2000, 52 (4) 673-751;

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Review ArticleReview

The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer

Elliott Middleton, Chithan Kandaswami and Theoharis C. Theoharides
Pharmacological Reviews December 1, 2000, 52 (4) 673-751;
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  • Article
    • Abstract
    • I. General Aspects
    • II. Effects on Mammalian Enzyme Systems
    • III. Modulation of the Functions of Inflammatory Cells
    • IV. Effects of Flavonoids on Other Cells
    • V. Endocrine and Metabolic Effects
    • VI. Antiviral Effects
    • VII. Antitoxic, Hepatoprotective, and Cytoprotective Effects
    • VIII. Antioxidant Activity
    • IX. Actions in Relation to Coronary Artery Disease and Vascular Disorders
    • X. Flavonoid-Vitamin C Interactions
    • XI. Cancer-Related Properties
    • XII. Effects on Xenobiotic Metabolism
    • XIII. Concluding Remarks
    • Acknowlegments
    • Footnotes
    • Abbreviations
    • References
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