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Review ArticleReview

Proteinase-Activated Receptors

Scott R. Macfarlane, Michael J. Seatter, Toru Kanke, Gary D. Hunter and Robin Plevin
Pharmacological Reviews June 2001, 53 (2) 245-282;
Scott R. Macfarlane
Department of Physiology and Pharmacology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, Glasgow, United Kingdom
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Michael J. Seatter
Department of Physiology and Pharmacology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, Glasgow, United Kingdom
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Toru Kanke
Department of Physiology and Pharmacology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, Glasgow, United Kingdom
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Gary D. Hunter
Department of Physiology and Pharmacology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, Glasgow, United Kingdom
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Robin Plevin
Department of Physiology and Pharmacology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, Glasgow, United Kingdom
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Article Information

vol. 53 no. 2 245-282

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online June 1, 2001.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Scott R. Macfarlane,
  2. Michael J. Seatter,
  3. Toru Kanke,
  4. Gary D. Hunter, and
  5. Robin Plevin1
  1. Department of Physiology and Pharmacology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, Glasgow, United Kingdom
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Pharmacological Reviews: 53 (2)
Pharmacological Reviews
Vol. 53, Issue 2
1 Jun 2001
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Review ArticleReview

Proteinase-Activated Receptors

Scott R. Macfarlane, Michael J. Seatter, Toru Kanke, Gary D. Hunter and Robin Plevin
Pharmacological Reviews June 1, 2001, 53 (2) 245-282;

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Review ArticleReview

Proteinase-Activated Receptors

Scott R. Macfarlane, Michael J. Seatter, Toru Kanke, Gary D. Hunter and Robin Plevin
Pharmacological Reviews June 1, 2001, 53 (2) 245-282;
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  • Article
    • Abstract
    • I. Introduction
    • II. Historical Perspectives—Cellular Effects of Thrombin and the Cloning of the Thrombin Receptor, Proteinase-Activated Receptor-1
    • III. Pharmacology of Proteinase-Activated Receptor-1
    • IV. Functional Responses to Proteinase-Activated Receptor-1 Activation
    • V. Proteinase-Activated Receptor-1-Mediated Cellular Signaling
    • VI. Desensitization of Proteinase-Activated Receptor-1
    • VII. Cloning of Proteinase-Activated Receptor-2
    • VIII. Functional Responses to Proteinase-Activated Receptor-2 Activation
    • IX. Endogenous Activators of Proteinase-Activated Receptor-2
    • X. Pharmacology of Proteinase-Activated Receptor-2
    • XI. Proteinase-Activated Receptor-2-Mediated Intracellular Signaling
    • XII. Proteinase-Activated Receptor-2 Desensitization
    • XIII. Identification and Function of Proteinase-Activated Receptor-3 and Proteinase-Activated Receptor-4
    • XIV. Functional and Molecular Interactions Between Proteinase-Activated Receptors
    • XV. Proteinase-Activated Receptors as Therapeutic Targets in Disease States
    • XVI. Future Perspectives
    • Acknowledgments
    • Footnotes
    • Abbreviations
    • References
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