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Review ArticleReview

G Protein-Coupled Receptor Allosterism and Complexing

Arthur Christopoulos and Terry Kenakin
Pharmacological Reviews June 2002, 54 (2) 323-374; DOI: https://doi.org/10.1124/pr.54.2.323
Arthur Christopoulos
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Terry Kenakin
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Article Information

vol. 54 no. 2 323-374
DOI 
https://doi.org/10.1124/pr.54.2.323
PubMed 
12037145

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online June 1, 2002.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Arthur Christopoulos1 and
  2. Terry Kenakin2
  1. 1Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia (A.C.); and 27TM Pharmacology Systems Research, Glaxo Smith-Kline Research and Development, Research Triangle Park, North Carolina (T.K.)
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Pharmacological Reviews: 54 (2)
Pharmacological Reviews
Vol. 54, Issue 2
1 Jun 2002
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Review ArticleReview

G Protein-Coupled Receptor Allosterism and Complexing

Arthur Christopoulos and Terry Kenakin
Pharmacological Reviews June 1, 2002, 54 (2) 323-374; DOI: https://doi.org/10.1124/pr.54.2.323

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Review ArticleReview

G Protein-Coupled Receptor Allosterism and Complexing

Arthur Christopoulos and Terry Kenakin
Pharmacological Reviews June 1, 2002, 54 (2) 323-374; DOI: https://doi.org/10.1124/pr.54.2.323
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Jump to section

  • Article
    • Abstract
    • I. Introduction
    • II. Allosteric Receptor Models of G Protein-Coupled Receptors
    • III. Detecting Allosteric Interactions
    • IV. Usefulness of Allosteric Modulators
    • V. Location of the Allosteric Site(s)
    • VI. Endogenous Allosteric Modulators
    • VII. G Protein-Coupled Receptor Complexing
    • VIII. Conclusions
    • Acknowledgments
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
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  • International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology
  • G Protein Modulation of Voltage-Gated Calcium Channels
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