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Review ArticleReview

Impact of Drug Transporter Studies on Drug Discovery and Development

Naomi Mizuno, Takuro Niwa, Yoshihisa Yotsumoto and Yuichi Sugiyama
Pharmacological Reviews September 2003, 55 (3) 425-461; DOI: https://doi.org/10.1124/pr.55.3.1
Naomi Mizuno
Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan; and Pharmacokinetics Laboratory, Mitsubishi Pharma Corporation, Chiba, Japan
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Takuro Niwa
Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan; and Pharmacokinetics Laboratory, Mitsubishi Pharma Corporation, Chiba, Japan
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Yoshihisa Yotsumoto
Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan; and Pharmacokinetics Laboratory, Mitsubishi Pharma Corporation, Chiba, Japan
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Yuichi Sugiyama
Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan; and Pharmacokinetics Laboratory, Mitsubishi Pharma Corporation, Chiba, Japan
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Article Information

vol. 55 no. 3 425-461
DOI 
https://doi.org/10.1124/pr.55.3.1
PubMed 
12869659

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online August 12, 2003.

Article Versions

  • Earlier version (July 17, 2003 - 12:25).
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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Naomi Mizuno,
  2. Takuro Niwa,
  3. Yoshihisa Yotsumoto, and
  4. Yuichi Sugiyama
  1. Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan; and Pharmacokinetics Laboratory, Mitsubishi Pharma Corporation, Chiba, Japan
  1. Address correspondence to: Dr. Yuichi Sugiyama, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Pharmacological Reviews: 55 (3)
Pharmacological Reviews
Vol. 55, Issue 3
1 Sep 2003
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Review ArticleReview

Impact of Drug Transporter Studies on Drug Discovery and Development

Naomi Mizuno, Takuro Niwa, Yoshihisa Yotsumoto and Yuichi Sugiyama
Pharmacological Reviews September 1, 2003, 55 (3) 425-461; DOI: https://doi.org/10.1124/pr.55.3.1

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Review ArticleReview

Impact of Drug Transporter Studies on Drug Discovery and Development

Naomi Mizuno, Takuro Niwa, Yoshihisa Yotsumoto and Yuichi Sugiyama
Pharmacological Reviews September 1, 2003, 55 (3) 425-461; DOI: https://doi.org/10.1124/pr.55.3.1
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  • Article
    • Abstract
    • I. Introduction
    • II. Strategies for Drug Discovery Using Transporters
    • III. Clinical Implications of Transporter-Mediated Drug Interactions
    • IV. Possible Strategies for Drug Discovery Using Drug Transporter Inhibitors
    • V. Species and Gender Differences in Drug Transporters
    • VI. Synergistic Role of Metabolic Enzymes and Transporters
    • VII. The Regulation Mechanisms of Drug Transporters
    • VIII. Polymorphisms of Drug Transporters
    • IX. Methods for Assessing Drug Transporter Activities in Drug Discovery
    • Footnotes
    • References
  • Figures & Data
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