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Review ArticleReview

Induction of Drug Metabolism: The Role of Nuclear Receptors

Christoph Handschin and Urs A. Meyer
Pharmacological Reviews December 2003, 55 (4) 649-673; DOI: https://doi.org/10.1124/pr.55.4.2
Christoph Handschin
Division of Pharmacology/Neurobiology, Biozentrum of the University of Basel, Basel, Switzerland
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Urs A. Meyer
Division of Pharmacology/Neurobiology, Biozentrum of the University of Basel, Basel, Switzerland
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Article Information

vol. 55 no. 4 649-673
DOI 
https://doi.org/10.1124/pr.55.4.2
PubMed 
14657421

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online December 2, 2003.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Christoph Handschin1 and
  2. Urs A. Meyer
  1. Division of Pharmacology/Neurobiology, Biozentrum of the University of Basel, Basel, Switzerland
  1. Address correspondence to: Urs A. Meyer, Division of Pharmacology/Neurobiology, Biozentrum of the University of Basel, Klingelbergstrasse 50-70, CH-4056 Basel, Switzerland. E-mail: ursa.meyer{at}unibas.ch
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Pharmacological Reviews: 55 (4)
Pharmacological Reviews
Vol. 55, Issue 4
1 Dec 2003
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Review ArticleReview

Induction of Drug Metabolism: The Role of Nuclear Receptors

Christoph Handschin and Urs A. Meyer
Pharmacological Reviews December 1, 2003, 55 (4) 649-673; DOI: https://doi.org/10.1124/pr.55.4.2

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Review ArticleReview

Induction of Drug Metabolism: The Role of Nuclear Receptors

Christoph Handschin and Urs A. Meyer
Pharmacological Reviews December 1, 2003, 55 (4) 649-673; DOI: https://doi.org/10.1124/pr.55.4.2
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  • Article
    • Abstract
    • I. Introduction
    • II. Drug-Mediated Induction of Cytochromes P450
    • III. Drug-Response Elements in Inducible Cytochrome P450 Genes
    • IV. Nuclear Receptors Involved in Drug Induction of Cytochromes P450
    • V. Endogenous Roles of the Xenosensors
    • VI. Clinical Relevance of Induction
    • VII. Open Questions
    • VIII. Outlook
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
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  • eLetters
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