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Research ArticleArticle

Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation

Anna Catania, Stefano Gatti, Gualtiero Colombo and James M. Lipton
Pharmacological Reviews March 2004, 56 (1) 1-29; DOI: https://doi.org/10.1124/pr.56.1.1
Anna Catania
Divisions of Internal Medicine (A.C., G.C.) and Liver Transplantation (S.G.), Ospedale Maggiore di Milano, Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy; and Zengen, Inc. (J.M.L.), Woodland Hills, California
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Stefano Gatti
Divisions of Internal Medicine (A.C., G.C.) and Liver Transplantation (S.G.), Ospedale Maggiore di Milano, Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy; and Zengen, Inc. (J.M.L.), Woodland Hills, California
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Gualtiero Colombo
Divisions of Internal Medicine (A.C., G.C.) and Liver Transplantation (S.G.), Ospedale Maggiore di Milano, Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy; and Zengen, Inc. (J.M.L.), Woodland Hills, California
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James M. Lipton
Divisions of Internal Medicine (A.C., G.C.) and Liver Transplantation (S.G.), Ospedale Maggiore di Milano, Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy; and Zengen, Inc. (J.M.L.), Woodland Hills, California
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Article Information

vol. 56 no. 1 1-29
DOI 
https://doi.org/10.1124/pr.56.1.1
PubMed 
15001661

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online March 4, 2004.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anna Catania,
  2. Stefano Gatti,
  3. Gualtiero Colombo, and
  4. James M. Lipton
  1. Divisions of Internal Medicine (A.C., G.C.) and Liver Transplantation (S.G.), Ospedale Maggiore di Milano, Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy; and Zengen, Inc. (J.M.L.), Woodland Hills, California
  1. Address correspondence to: Dr. Anna Catania, Divisione di Medicina Interna I, Pad. Granelli, Ospedale Maggiore di Milano IRCCS, Via F. Sforza 35, Milano 20122, Italy. E-mail: anna.catania{at}unimi.it
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Pharmacological Reviews: 56 (1)
Pharmacological Reviews
Vol. 56, Issue 1
1 Mar 2004
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Research ArticleArticle

Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation

Anna Catania, Stefano Gatti, Gualtiero Colombo and James M. Lipton
Pharmacological Reviews March 1, 2004, 56 (1) 1-29; DOI: https://doi.org/10.1124/pr.56.1.1

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Research ArticleArticle

Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation

Anna Catania, Stefano Gatti, Gualtiero Colombo and James M. Lipton
Pharmacological Reviews March 1, 2004, 56 (1) 1-29; DOI: https://doi.org/10.1124/pr.56.1.1
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  • Article
    • Abstract
    • I. Introduction
    • II. Proopiomelanocortin Gene, Gene Expression, and Post-Translational Processing
    • III. Melanocortin Receptors and Their Endogenous Antagonists
    • IV. Intracellular Signaling
    • V. Structure-Activity Relationship of Melanocortin Peptides
    • VI. Mechanism of the Anti-Inflammatory Action of Melanocortins
    • VII. Antipyretic Influences of Melanocortins
    • VIII. Changes in Endogenous α-Melanocyte-Stimulating Hormone in Inflammatory Disorders
    • IX. Potential Therapeutic Targets Based on Preclinical Studies in Inflammatory Disorders
    • X. Advantages over Currently Used Anti-Inflammatory Drugs and Potential Disadvantages
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    • References
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