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Research ArticleArticle

Enzyme-Catalyzed Activation of Anticancer Prodrugs

Martijn Rooseboom, Jan N. M. Commandeur and Nico P. E. Vermeulen
Pharmacological Reviews March 2004, 56 (1) 53-102; DOI: https://doi.org/10.1124/pr.56.1.3
Martijn Rooseboom
Leiden/Amsterdam Center for Drug Research (L.A.C.D.R.), Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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Jan N. M. Commandeur
Leiden/Amsterdam Center for Drug Research (L.A.C.D.R.), Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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Nico P. E. Vermeulen
Leiden/Amsterdam Center for Drug Research (L.A.C.D.R.), Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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Article Information

vol. 56 no. 1 53-102
DOI 
https://doi.org/10.1124/pr.56.1.3
PubMed 
15001663

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online March 4, 2004.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Martijn Rooseboom,
  2. Jan N. M. Commandeur, and
  3. Nico P. E. Vermeulen
  1. Leiden/Amsterdam Center for Drug Research (L.A.C.D.R.), Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
  1. Address correspondence to: Prof. Dr. Nico P. E. Vermeulen, Leiden/Amsterdam Center for Drug Research (L.A.C.D.R.), Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, Amsterdam, The Netherlands. E-mail: vermeule{at}chem.vu.nl
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Pharmacological Reviews: 56 (1)
Pharmacological Reviews
Vol. 56, Issue 1
1 Mar 2004
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Research ArticleArticle

Enzyme-Catalyzed Activation of Anticancer Prodrugs

Martijn Rooseboom, Jan N. M. Commandeur and Nico P. E. Vermeulen
Pharmacological Reviews March 1, 2004, 56 (1) 53-102; DOI: https://doi.org/10.1124/pr.56.1.3

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Research ArticleArticle

Enzyme-Catalyzed Activation of Anticancer Prodrugs

Martijn Rooseboom, Jan N. M. Commandeur and Nico P. E. Vermeulen
Pharmacological Reviews March 1, 2004, 56 (1) 53-102; DOI: https://doi.org/10.1124/pr.56.1.3
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  • Article
    • Abstract
    • I. Introduction
    • II. Prodrugs Activated by Endogenous Enzymes
    • III. Prodrugs Activated by Antibody-, Gene-, and Virus-Directed Enzyme Prodrug Therapy Approaches
    • IV. Concluding Remarks and Future Perspectives
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