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Research ArticleArticle

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

Daniel L. Simmons, Regina M. Botting and Timothy Hla
Pharmacological Reviews September 2004, 56 (3) 387-437; DOI: https://doi.org/10.1124/pr.56.3.3
Daniel L. Simmons
The Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah (D.L.S.); The William Harvey Research Institute, St. Bartholomew's and William and Mary Medical College, London, England (R.M.B.); and Center for Vascular Biology, Department of Physiology, University of Connecticut School of Medicine, Farmington, Connecticut (T.H.)
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Regina M. Botting
The Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah (D.L.S.); The William Harvey Research Institute, St. Bartholomew's and William and Mary Medical College, London, England (R.M.B.); and Center for Vascular Biology, Department of Physiology, University of Connecticut School of Medicine, Farmington, Connecticut (T.H.)
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Timothy Hla
The Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah (D.L.S.); The William Harvey Research Institute, St. Bartholomew's and William and Mary Medical College, London, England (R.M.B.); and Center for Vascular Biology, Department of Physiology, University of Connecticut School of Medicine, Farmington, Connecticut (T.H.)
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Article Information

vol. 56 no. 3 387-437
DOI 
https://doi.org/10.1124/pr.56.3.3
PubMed 
15317910

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online August 18, 2004.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Daniel L. Simmons,
  2. Regina M. Botting, and
  3. Timothy Hla
  1. The Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah (D.L.S.); The William Harvey Research Institute, St. Bartholomew's and William and Mary Medical College, London, England (R.M.B.); and Center for Vascular Biology, Department of Physiology, University of Connecticut School of Medicine, Farmington, Connecticut (T.H.)
  1. Address correspondence to: Daniel L. Simmons, Department of Chemistry and Biochemistry, E280 BNSN, Brigham Young University, Provo, UT 84604. E-mail: dan_simmons{at}byu.edu
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Pharmacological Reviews: 56 (3)
Pharmacological Reviews
Vol. 56, Issue 3
1 Sep 2004
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Research ArticleArticle

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

Daniel L. Simmons, Regina M. Botting and Timothy Hla
Pharmacological Reviews September 1, 2004, 56 (3) 387-437; DOI: https://doi.org/10.1124/pr.56.3.3

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Research ArticleArticle

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

Daniel L. Simmons, Regina M. Botting and Timothy Hla
Pharmacological Reviews September 1, 2004, 56 (3) 387-437; DOI: https://doi.org/10.1124/pr.56.3.3
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  • Article
    • Abstract
    • I. Cyclooxygenase Isozymes
    • II. Pharmacological Actions of Cyclooxygenase Isozyme-Generated Prostanoids
    • III. Regulation of Expression of Cyclooxygenase-1 and -2
    • IV. Cyclooxygenase Isozymes in Human Disease
    • V. Cyclooxygenase Isozymes and the Future
    • Acknowledgments
    • Footnotes
    • References
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