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Research ArticleArticle

Vascular Endothelial Growth Factor and Angiogenesis

Ann Hoeben, Bart Landuyt, Martin S. Highley, Hans Wildiers, Allan T. Van Oosterom and Ernst A. De Bruijn
Pharmacological Reviews December 2004, 56 (4) 549-580; DOI: https://doi.org/10.1124/pr.56.4.3
Ann Hoeben
Laboratory of Experimental Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium (A.H., B.L., A.T.V.O., E.A.D.B.); and Department of Cancer Medicine, Ninewells Hospital, Dundee, United Kingdom (M.S.H.)
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Bart Landuyt
Laboratory of Experimental Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium (A.H., B.L., A.T.V.O., E.A.D.B.); and Department of Cancer Medicine, Ninewells Hospital, Dundee, United Kingdom (M.S.H.)
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Martin S. Highley
Laboratory of Experimental Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium (A.H., B.L., A.T.V.O., E.A.D.B.); and Department of Cancer Medicine, Ninewells Hospital, Dundee, United Kingdom (M.S.H.)
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Hans Wildiers
Laboratory of Experimental Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium (A.H., B.L., A.T.V.O., E.A.D.B.); and Department of Cancer Medicine, Ninewells Hospital, Dundee, United Kingdom (M.S.H.)
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Allan T. Van Oosterom
Laboratory of Experimental Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium (A.H., B.L., A.T.V.O., E.A.D.B.); and Department of Cancer Medicine, Ninewells Hospital, Dundee, United Kingdom (M.S.H.)
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Ernst A. De Bruijn
Laboratory of Experimental Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium (A.H., B.L., A.T.V.O., E.A.D.B.); and Department of Cancer Medicine, Ninewells Hospital, Dundee, United Kingdom (M.S.H.)
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Abstract

Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various ischemic and inflammatory diseases. A rich variety of pro- and antiangiogenic molecules have already been discovered. Vascular endothelial growth factor (VEGF) is an interesting inducer of angiogenesis and lymphangiogenesis, because it is a highly specific mitogen for endothelial cells. Signal transduction involves binding to tyrosine kinase receptors and results in endothelial cell proliferation, migration, and new vessel formation. In this article, the role of VEGF in physiological and pathological processes is reviewed. We also discuss how modulation of VEGF expression creates new therapeutic possibilities and describe recent developments in this field.

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Pharmacological Reviews: 56 (4)
Pharmacological Reviews
Vol. 56, Issue 4
1 Dec 2004
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Research ArticleArticle

Vascular Endothelial Growth Factor and Angiogenesis

Ann Hoeben, Bart Landuyt, Martin S. Highley, Hans Wildiers, Allan T. Van Oosterom and Ernst A. De Bruijn
Pharmacological Reviews December 1, 2004, 56 (4) 549-580; DOI: https://doi.org/10.1124/pr.56.4.3

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Research ArticleArticle

Vascular Endothelial Growth Factor and Angiogenesis

Ann Hoeben, Bart Landuyt, Martin S. Highley, Hans Wildiers, Allan T. Van Oosterom and Ernst A. De Bruijn
Pharmacological Reviews December 1, 2004, 56 (4) 549-580; DOI: https://doi.org/10.1124/pr.56.4.3
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  • Article
    • Abstract
    • I. Introduction
    • II. Vascular Endothelial Growth Factor
    • III. Vascular Endothelial Growth Factor in Tumor Growth
    • IV. Vascular Endothelial Growth Factor in Nonmalignant Disease
    • V. Conclusions and Future Directions
    • Acknowledgments
    • Footnotes
    • References
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