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History
- Published online February 24, 2005.
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The American Society for Pharmacology and Experimental Therapeutics
Author Information
- Aric Gregson and
- Christopher V. Plowe
- Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland
- Address correspondence to: Dr. C. Plowe, Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 Room 480, Baltimore, MD 21201. E-mail: cplowe{at}medicine.umaryland.edu
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- Article
- Abstract
- I. Introduction
- II. Malaria Parasite Drug Resistance
- III. Dihydrofolate Reductase-Thymidylate Synthase
- IV. Pyrophosphokinase-Dihydropteroate Synthase
- V. Parasitologic Resistance Does Not Equal Clinical Failure
- VI. Molecular Assays
- VII. Molecular Epidemiological Studies
- VIII. Using Genotype to Predict Clinical Failure
- IX. Other Antifolates
- X. New Directions—Drug Development
- XI. Summary
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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