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Research ArticleArticle

Mechanisms of Resistance of Malaria Parasites to Antifolates

Aric Gregson and Christopher V. Plowe
Pharmacological Reviews March 2005, 57 (1) 117-145; DOI: https://doi.org/10.1124/pr.57.1.4
Aric Gregson
Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland
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Christopher V. Plowe
Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland
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Article Information

vol. 57 no. 1 117-145
DOI 
https://doi.org/10.1124/pr.57.1.4
PubMed 
15734729

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online February 24, 2005.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Aric Gregson and
  2. Christopher V. Plowe
  1. Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland
  1. Address correspondence to: Dr. C. Plowe, Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 Room 480, Baltimore, MD 21201. E-mail: cplowe{at}medicine.umaryland.edu
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Pharmacological Reviews: 57 (1)
Pharmacological Reviews
Vol. 57, Issue 1
1 Mar 2005
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Research ArticleArticle

Mechanisms of Resistance of Malaria Parasites to Antifolates

Aric Gregson and Christopher V. Plowe
Pharmacological Reviews March 1, 2005, 57 (1) 117-145; DOI: https://doi.org/10.1124/pr.57.1.4

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Research ArticleArticle

Mechanisms of Resistance of Malaria Parasites to Antifolates

Aric Gregson and Christopher V. Plowe
Pharmacological Reviews March 1, 2005, 57 (1) 117-145; DOI: https://doi.org/10.1124/pr.57.1.4
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  • Article
    • Abstract
    • I. Introduction
    • II. Malaria Parasite Drug Resistance
    • III. Dihydrofolate Reductase-Thymidylate Synthase
    • IV. Pyrophosphokinase-Dihydropteroate Synthase
    • V. Parasitologic Resistance Does Not Equal Clinical Failure
    • VI. Molecular Assays
    • VII. Molecular Epidemiological Studies
    • VIII. Using Genotype to Predict Clinical Failure
    • IX. Other Antifolates
    • X. New Directions—Drug Development
    • XI. Summary
    • Footnotes
    • References
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