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Research ArticleArticle

Metabolism and Disposition Kinetics of Nicotine

Janne Hukkanen, Pleyton Jacob III and Neal L. Benowitz
Pharmacological Reviews March 2005, 57 (1) 79-115; DOI: https://doi.org/10.1124/pr.57.1.3
Janne Hukkanen
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and the Departments of Medicine and Psychiatry, University of California, San Francisco, California
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Pleyton Jacob III
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and the Departments of Medicine and Psychiatry, University of California, San Francisco, California
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Neal L. Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and the Departments of Medicine and Psychiatry, University of California, San Francisco, California
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Article Information

vol. 57 no. 1 79-115
DOI 
https://doi.org/10.1124/pr.57.1.3
PubMed 
15734728

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online February 24, 2005.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Janne Hukkanen,
  2. Pleyton Jacob III, and
  3. Neal L. Benowitz
  1. Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and the Departments of Medicine and Psychiatry, University of California, San Francisco, California
  1. Address correspondence to: Dr. Neal L. Benowitz, Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, Box 1220, San Francisco, CA 94143-1220. E-mail: nbeno{at}itsa.ucsf.edu
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Pharmacological Reviews: 57 (1)
Pharmacological Reviews
Vol. 57, Issue 1
1 Mar 2005
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Research ArticleArticle

Metabolism and Disposition Kinetics of Nicotine

Janne Hukkanen, Pleyton Jacob and Neal L. Benowitz
Pharmacological Reviews March 1, 2005, 57 (1) 79-115; DOI: https://doi.org/10.1124/pr.57.1.3

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Research ArticleArticle

Metabolism and Disposition Kinetics of Nicotine

Janne Hukkanen, Pleyton Jacob and Neal L. Benowitz
Pharmacological Reviews March 1, 2005, 57 (1) 79-115; DOI: https://doi.org/10.1124/pr.57.1.3
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  • Article
    • Abstract
    • I. Introduction
    • II. Nicotine and Related Alkaloids in Tobacco Products
    • III. Absorption of Nicotine from Tobacco Smoke and Nicotine Medications
    • IV. Distribution of Nicotine in Body Tissues
    • V. Nicotine and Cotinine Blood Levels during Tobacco Use and Nicotine Replacement Therapy
    • VI. Metabolism of Nicotine
    • VII. Excretion
    • VIII. Species Differences in Nicotine Metabolism
    • IX. Metabolism of Minor Alkaloids of Tobacco
    • X. Pharmacokinetics and Metabolism of Nicotine Analogs
    • XI. Conclusions and Areas for Further Study
    • Acknowledgments
    • Footnotes
    • References
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  • PDF

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