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Research ArticleArticle

Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance

Steven C. Prinster, Chris Hague and Randy A. Hall
Pharmacological Reviews September 2005, 57 (3) 289-298; DOI: https://doi.org/10.1124/pr.57.3.1
Steven C. Prinster
Department of Pharmacology, Emory University School of Medicine, Atlanta Georgia
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Chris Hague
Department of Pharmacology, Emory University School of Medicine, Atlanta Georgia
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Randy A. Hall
Department of Pharmacology, Emory University School of Medicine, Atlanta Georgia
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Abstract

G protein-coupled receptors (GPCRs) are cell surface receptors that mediate physiological responses to a diverse array of stimuli. GPCRs have traditionally been thought to act as monomers, but recent evidence suggests that GPCRs may form dimers (or higher-order oligomers) as part of their normal trafficking and function. In fact, certain GPCRs seem to have a strict requirement for heterodimerization to attain proper surface expression and functional activity. Even those GPCRs that do not absolutely require heterodimerization may still specifically associate with other GPCR subtypes, sometimes resulting in dramatic effects on receptor pharmacology, signaling, and/or internalization. Understanding the specificity and functional significance of GPCR heterodimerization is of tremendous clinical importance since GPCRs are the molecular targets for numerous therapeutic drugs.

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Pharmacological Reviews: 57 (3)
Pharmacological Reviews
Vol. 57, Issue 3
1 Sep 2005
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Research ArticleArticle

Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance

Steven C. Prinster, Chris Hague and Randy A. Hall
Pharmacological Reviews September 1, 2005, 57 (3) 289-298; DOI: https://doi.org/10.1124/pr.57.3.1

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Research ArticleArticle

Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance

Steven C. Prinster, Chris Hague and Randy A. Hall
Pharmacological Reviews September 1, 2005, 57 (3) 289-298; DOI: https://doi.org/10.1124/pr.57.3.1
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