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OtherReview Article

The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer

Danuta S. Kalinowski and Des R. Richardson
Pharmacological Reviews December 2005, 57 (4) 547-583; DOI: https://doi.org/10.1124/pr.57.4.2
Danuta S. Kalinowski
Iron Metabolism and Chelation Program, Children's Cancer Institute Australia for Medical Research, Sydney, New South Wales, Australia
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Des R. Richardson
Iron Metabolism and Chelation Program, Children's Cancer Institute Australia for Medical Research, Sydney, New South Wales, Australia
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Article Information

vol. 57 no. 4 547-583
DOI 
https://doi.org/10.1124/pr.57.4.2
PubMed 
16382108

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online December 28, 2005.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Danuta S. Kalinowski and
  2. Des R. Richardson
  1. Iron Metabolism and Chelation Program, Children's Cancer Institute Australia for Medical Research, Sydney, New South Wales, Australia
  1. Address correspondence to: Dr. D. R. Richardson, The Iron Metabolism and Chelation Program, Children's Cancer Institute Australia for Medical Research, P.O. Box 81, High Street, Randwick, Sydney, New South Wales, 2031 Australia. E-mail: d.richardson{at}ccia.org.au
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Pharmacological Reviews: 57 (4)
Pharmacological Reviews
Vol. 57, Issue 4
1 Dec 2005
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OtherReview Article

The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer

Danuta S. Kalinowski and Des R. Richardson
Pharmacological Reviews December 1, 2005, 57 (4) 547-583; DOI: https://doi.org/10.1124/pr.57.4.2

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OtherReview Article

The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer

Danuta S. Kalinowski and Des R. Richardson
Pharmacological Reviews December 1, 2005, 57 (4) 547-583; DOI: https://doi.org/10.1124/pr.57.4.2
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  • Article
    • Abstract
    • I. Introduction
    • II. Redox Activity of Iron
    • III. Iron Metabolism in Normal Cells
    • IV. Iron Overload Disease
    • V. Targeting Iron in Cancer Therapy: Iron Metabolism in Neoplastic Cells
    • VI. The Evolution of Iron Chelators
    • VII. Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
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