OtherReview Article
The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo
Nan Chiang, Charles N. Serhan, Sven-Erik Dahlén, Jeffrey M. Drazen, Douglas W. P. Hay, G. Enrico Rovati, Takao Shimizu, Takehiko Yokomizo and Charles Brink
Pharmacological Reviews September 2006, 58 (3) 463-487; DOI: https://doi.org/10.1124/pr.58.3.4
Nan Chiang
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine (N.C., C.N.S.), and Department of Medicine (J.M.D.), Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts; Department of Oral Medicine, Infection, and Immunity (C.N.S.), Harvard School of Dental Medicine, Boston, Massachusetts; Unit for Experimental Asthma and Allergy, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.-E.D.); GlaxoSmithKline, King of Prussia, Pennsylvania (D.W.P.H.); Division of Molecular Pharmacology, Pharmacological Sciences, Milan, Italy (G.E.R.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan (T.S.); Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fu Kuoka, Japan (T.Y.); and Institut National de la Santé et de la Recherche Médicale U698, Hôpital Xavier Bichat secteur Claude Bernard, Paris, France (C.B.)
Charles N. Serhan
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine (N.C., C.N.S.), and Department of Medicine (J.M.D.), Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts; Department of Oral Medicine, Infection, and Immunity (C.N.S.), Harvard School of Dental Medicine, Boston, Massachusetts; Unit for Experimental Asthma and Allergy, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.-E.D.); GlaxoSmithKline, King of Prussia, Pennsylvania (D.W.P.H.); Division of Molecular Pharmacology, Pharmacological Sciences, Milan, Italy (G.E.R.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan (T.S.); Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fu Kuoka, Japan (T.Y.); and Institut National de la Santé et de la Recherche Médicale U698, Hôpital Xavier Bichat secteur Claude Bernard, Paris, France (C.B.)
Sven-Erik Dahlén
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine (N.C., C.N.S.), and Department of Medicine (J.M.D.), Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts; Department of Oral Medicine, Infection, and Immunity (C.N.S.), Harvard School of Dental Medicine, Boston, Massachusetts; Unit for Experimental Asthma and Allergy, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.-E.D.); GlaxoSmithKline, King of Prussia, Pennsylvania (D.W.P.H.); Division of Molecular Pharmacology, Pharmacological Sciences, Milan, Italy (G.E.R.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan (T.S.); Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fu Kuoka, Japan (T.Y.); and Institut National de la Santé et de la Recherche Médicale U698, Hôpital Xavier Bichat secteur Claude Bernard, Paris, France (C.B.)
Jeffrey M. Drazen
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine (N.C., C.N.S.), and Department of Medicine (J.M.D.), Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts; Department of Oral Medicine, Infection, and Immunity (C.N.S.), Harvard School of Dental Medicine, Boston, Massachusetts; Unit for Experimental Asthma and Allergy, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.-E.D.); GlaxoSmithKline, King of Prussia, Pennsylvania (D.W.P.H.); Division of Molecular Pharmacology, Pharmacological Sciences, Milan, Italy (G.E.R.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan (T.S.); Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fu Kuoka, Japan (T.Y.); and Institut National de la Santé et de la Recherche Médicale U698, Hôpital Xavier Bichat secteur Claude Bernard, Paris, France (C.B.)
Douglas W. P. Hay
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine (N.C., C.N.S.), and Department of Medicine (J.M.D.), Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts; Department of Oral Medicine, Infection, and Immunity (C.N.S.), Harvard School of Dental Medicine, Boston, Massachusetts; Unit for Experimental Asthma and Allergy, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.-E.D.); GlaxoSmithKline, King of Prussia, Pennsylvania (D.W.P.H.); Division of Molecular Pharmacology, Pharmacological Sciences, Milan, Italy (G.E.R.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan (T.S.); Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fu Kuoka, Japan (T.Y.); and Institut National de la Santé et de la Recherche Médicale U698, Hôpital Xavier Bichat secteur Claude Bernard, Paris, France (C.B.)
G. Enrico Rovati
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine (N.C., C.N.S.), and Department of Medicine (J.M.D.), Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts; Department of Oral Medicine, Infection, and Immunity (C.N.S.), Harvard School of Dental Medicine, Boston, Massachusetts; Unit for Experimental Asthma and Allergy, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.-E.D.); GlaxoSmithKline, King of Prussia, Pennsylvania (D.W.P.H.); Division of Molecular Pharmacology, Pharmacological Sciences, Milan, Italy (G.E.R.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan (T.S.); Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fu Kuoka, Japan (T.Y.); and Institut National de la Santé et de la Recherche Médicale U698, Hôpital Xavier Bichat secteur Claude Bernard, Paris, France (C.B.)
Takao Shimizu
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine (N.C., C.N.S.), and Department of Medicine (J.M.D.), Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts; Department of Oral Medicine, Infection, and Immunity (C.N.S.), Harvard School of Dental Medicine, Boston, Massachusetts; Unit for Experimental Asthma and Allergy, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.-E.D.); GlaxoSmithKline, King of Prussia, Pennsylvania (D.W.P.H.); Division of Molecular Pharmacology, Pharmacological Sciences, Milan, Italy (G.E.R.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan (T.S.); Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fu Kuoka, Japan (T.Y.); and Institut National de la Santé et de la Recherche Médicale U698, Hôpital Xavier Bichat secteur Claude Bernard, Paris, France (C.B.)
Takehiko Yokomizo
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine (N.C., C.N.S.), and Department of Medicine (J.M.D.), Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts; Department of Oral Medicine, Infection, and Immunity (C.N.S.), Harvard School of Dental Medicine, Boston, Massachusetts; Unit for Experimental Asthma and Allergy, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.-E.D.); GlaxoSmithKline, King of Prussia, Pennsylvania (D.W.P.H.); Division of Molecular Pharmacology, Pharmacological Sciences, Milan, Italy (G.E.R.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan (T.S.); Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fu Kuoka, Japan (T.Y.); and Institut National de la Santé et de la Recherche Médicale U698, Hôpital Xavier Bichat secteur Claude Bernard, Paris, France (C.B.)
Charles Brink
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine (N.C., C.N.S.), and Department of Medicine (J.M.D.), Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts; Department of Oral Medicine, Infection, and Immunity (C.N.S.), Harvard School of Dental Medicine, Boston, Massachusetts; Unit for Experimental Asthma and Allergy, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.-E.D.); GlaxoSmithKline, King of Prussia, Pennsylvania (D.W.P.H.); Division of Molecular Pharmacology, Pharmacological Sciences, Milan, Italy (G.E.R.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan (T.S.); Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fu Kuoka, Japan (T.Y.); and Institut National de la Santé et de la Recherche Médicale U698, Hôpital Xavier Bichat secteur Claude Bernard, Paris, France (C.B.)

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In this issue
OtherReview Article
The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo
Nan Chiang, Charles N. Serhan, Sven-Erik Dahlén, Jeffrey M. Drazen, Douglas W. P. Hay, G. Enrico Rovati, Takao Shimizu, Takehiko Yokomizo and Charles Brink
Pharmacological Reviews September 1, 2006, 58 (3) 463-487; DOI: https://doi.org/10.1124/pr.58.3.4
OtherReview Article
The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo
Nan Chiang, Charles N. Serhan, Sven-Erik Dahlén, Jeffrey M. Drazen, Douglas W. P. Hay, G. Enrico Rovati, Takao Shimizu, Takehiko Yokomizo and Charles Brink
Pharmacological Reviews September 1, 2006, 58 (3) 463-487; DOI: https://doi.org/10.1124/pr.58.3.4
Jump to section
- Article
- Abstract
- I. Introduction
- II. Production of Lipoxins
- III. Molecular Characterization of ALX, the Specific Receptor for Lipoxin A4
- IV. Flexibility of G Protein-Coupled Ligand-Receptor Interaction: Lipid-versus Peptide-Derived Ligands
- V. ALX: Historical Perspective and Connection to the FPR
- VI. “Aspirin-Triggered” Lipoxin-Generating Systems
- VII. Biological Significance of the Lipoxin-ALX System
- VIII. How Does Lipoxin A4 Induce Anti-Inflammatory and Proresolving Signaling?
- IX. Additional Receptors Involved in Lipoxin A4 and Aspirin-Triggered Lipoxin A4 in Vivo Actions
- X. Conclusions
- Acknowledgments
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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