Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use

Address correspondence to: Dr. Joseph A. Beavo, Department of Pharmacology, University of Washington Medical School, Health Sciences Building, Box 357280, Seattle, WA 98195-7280. E-mail: beavo{at}u.washington.edu

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	Abstract	Full	Pdf
Sep 2006	162	160	250
Oct 2006	125	122	198
Nov 2006	98	134	178
Dec 2006	90	90	128
Jan 2007	83	126	162
Feb 2007	83	100	108
Mar 2007	109	98	121
Apr 2007	96	103	125
May 2007	88	84	114
Jun 2007	66	62	94
Jul 2007	98	65	104
Aug 2007	63	56	63
Sep 2007	65	181	199
Oct 2007	59	171	182
Nov 2007	63	206	182
Dec 2007	88	125	147
Jan 2008	75	122	158
Feb 2008	76	195	173
Mar 2008	122	183	196
Apr 2008	165	210	231
May 2008	82	149	140
Jun 2008	68	149	157
Jul 2008	134	144	156
Aug 2008	127	137	111
Sep 2008	125	131	138
Oct 2008	145	141	122
Nov 2008	115	154	127
Dec 2008	93	147	107
Jan 2009	74	123	137
Feb 2009	82	150	126
Mar 2009	167	194	120
Apr 2009	105	121	137
May 2009	76	137	126
Jun 2009	88	165	114
Jul 2009	76	123	113
Aug 2009	70	77	95
Sep 2009	71	83	97
Oct 2009	83	105	109
Nov 2009	87	94	104
Dec 2009	96	34	211
Jan 2010	332	92	127
Feb 2010	172	109	111
Mar 2010	162	80	109
Apr 2010	93	120	64
May 2010	294	92	72
Jun 2010	222	108	88
Jul 2010	132	121	101
Aug 2010	155	93	86
Sep 2010	176	156	83
Oct 2010	151	122	97
Nov 2010	95	155	91
Dec 2010	80	138	83
Jan 2011	106	174	99
Feb 2011	89	159	94
Mar 2011	124	167	120
Apr 2011	100	162	117
May 2011	103	128	112
Jun 2011	97	75	109
Jul 2011	138	129	97
Aug 2011	153	198	144
Sep 2011	144	153	123
Oct 2011	137	195	107
Nov 2011	169	126	140
Dec 2011	113	113	109
Jan 2012	141	163	109
Feb 2012	144	178	135
Mar 2012	159	169	142
Apr 2012	154	170	142
May 2012	164	245	116
Jun 2012	140	212	141
Jul 2012	142	211	111
Aug 2012	122	189	117
Sep 2012	119	204	114
Oct 2012	200	217	148
Nov 2012	175	196	131
Dec 2012	180	181	130
Jan 2013	229	276	189
Feb 2013	161	231	147
Mar 2013	196	215	144
Apr 2013	186	228	118
May 2013	128	223	126
Jun 2013	66	136	94
Jul 2013	68	147	92
Aug 2013	79	151	92
Sep 2013	123	210	126
Oct 2013	141	251	118
Nov 2013	110	246	111
Dec 2013	115	175	99
Jan 2014	130	285	149
Feb 2014	98	362	148
Mar 2014	137	426	176
Apr 2014	147	351	128
May 2014	287	337	139
Jun 2014	188	296	126
Jul 2014	129	418	92
Aug 2014	109	430	109
Sep 2014	182	524	147
Oct 2014	95	922	121
Nov 2014	110	790	139
Dec 2014	127	575	96
Jan 2015	141	681	127
Feb 2015	116	753	96
Mar 2015	86	889	112
Apr 2015	148	806	128
May 2015	116	575	138
Jun 2015	86	522	114
Jul 2015	132	450	112
Aug 2015	107	307	110
Sep 2015	72	316	90
Oct 2015	69	425	93
Nov 2015	102	361	74
Dec 2015	132	359	95
Jan 2016	157	476	107
Feb 2016	144	440	103
Mar 2016	158	387	163
Apr 2016	157	490	144
May 2016	163	399	100
Jun 2016	132	326	92
Jul 2016	209	429	68
Aug 2016	130	376	77
Sep 2016	99	291	62
Oct 2016	15	274	55
Nov 2016	20	400	82
Dec 2016	15	343	61
Jan 2017	10	396	71
Feb 2017	33	365	99
Mar 2017	16	394	104
Apr 2017	19	321	80
May 2017	17	314	89
Jun 2017	27	325	72
Jul 2017	19	216	75
Aug 2017	27	257	71
Sep 2017	16	279	92
Oct 2017	16	448	83
Nov 2017	17	328	93
Dec 2017	9	210	112
Jan 2018	10	146	45
Feb 2018	12	213	59
Mar 2018	19	273	83
Apr 2018	12	458	82
May 2018	7	306	71
Jun 2018	28	210	75
Jul 2018	16	191	63
Aug 2018	10	320	64
Sep 2018	13	379	51
Oct 2018	16	484	92
Nov 2018	13	530	76
Dec 2018	459	124	44
Jan 2019	485	37	21
Feb 2019	388	27	22
Mar 2019	263	23	24
Apr 2019	207	30	19
May 2019	142	30	17
Jun 2019	166	37	26
Jul 2019	199	39	30
Aug 2019	199	39	26
Sep 2019	138	24	18
Oct 2019	211	44	30
Nov 2019	195	27	15
Dec 2019	163	278	22
Jan 2020	130	24	17
Feb 2020	167	29	13
Mar 2020	234	28	19
Apr 2020	257	21	16
May 2020	279	30	26
Jun 2020	195	12	9
Jul 2020	219	10	18
Aug 2020	161	8	12
Sep 2020	159	21	12
Oct 2020	230	31	21
Nov 2020	199	31	14
Dec 2020	5	3	3