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Inhibitors of Brain Phospholipase A2 Activity: Their Neuropharmacological Effects and Therapeutic Importance for the Treatment of Neurologic Disorders

Akhlaq A. Farooqui, Wei-Yi Ong and Lloyd A. Horrocks
Pharmacological Reviews September 2006, 58 (3) 591-620; DOI: https://doi.org/10.1124/pr.58.3.7
Akhlaq A. Farooqui
Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio (A.A.F., L.A.H.); and Department of Anatomy, National University of Singapore, Singapore, Singapore (W.-Y.O.)
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Wei-Yi Ong
Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio (A.A.F., L.A.H.); and Department of Anatomy, National University of Singapore, Singapore, Singapore (W.-Y.O.)
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Lloyd A. Horrocks
Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio (A.A.F., L.A.H.); and Department of Anatomy, National University of Singapore, Singapore, Singapore (W.-Y.O.)
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Article Information

vol. 58 no. 3 591-620
DOI 
https://doi.org/10.1124/pr.58.3.7
PubMed 
16968951

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 12, 2006.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Akhlaq A. Farooqui,
  2. Wei-Yi Ong, and
  3. Lloyd A. Horrocks
  1. Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio (A.A.F., L.A.H.); and Department of Anatomy, National University of Singapore, Singapore, Singapore (W.-Y.O.)
  1. Address correspondence to: Dr. Lloyd A. Horrocks, Department of Molecular and Cellular Biochemistry, 1645 Neil Ave., The Ohio State University, Columbus, OH 43210-1218. E-mail: horrocks.2{at}osu.edu
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Pharmacological Reviews: 58 (3)
Pharmacological Reviews
Vol. 58, Issue 3
1 Sep 2006
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OtherReview Article

Inhibitors of Brain Phospholipase A2 Activity: Their Neuropharmacological Effects and Therapeutic Importance for the Treatment of Neurologic Disorders

Akhlaq A. Farooqui, Wei-Yi Ong and Lloyd A. Horrocks
Pharmacological Reviews September 1, 2006, 58 (3) 591-620; DOI: https://doi.org/10.1124/pr.58.3.7

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OtherReview Article

Inhibitors of Brain Phospholipase A2 Activity: Their Neuropharmacological Effects and Therapeutic Importance for the Treatment of Neurologic Disorders

Akhlaq A. Farooqui, Wei-Yi Ong and Lloyd A. Horrocks
Pharmacological Reviews September 1, 2006, 58 (3) 591-620; DOI: https://doi.org/10.1124/pr.58.3.7
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  • Article
    • Abstract
    • I. Introduction
    • II. Multiplicity of Phospholipases A2 in Brain
    • III. Involvement of Phospholipase A2 Activity in Brain Injury
    • IV. Physiological and Pharmacological Effects of Phospholipase A2 Inhibitors
    • V. Phospholipase A2 Activity in Kainic Acid-Induced Neural Cell Injury
    • VI. Protection of Kainic Acid-Induced Neural Cell Injury by Phospholipase A2 Inhibitors
    • VII. Phospholipase A2 Activity in Neurological Disorders
    • VIII. Use of Phospholipase A2 Inhibitors for the Treatment of Neurological Disorders
    • IX. Prevention of Pain by Phospholipase A2 Inhibitors
    • X. Perspective and Direction for Future Studies
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
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