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OtherReview Article

Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

Ting-Chao Chou
Pharmacological Reviews September 2006, 58 (3) 621-681; DOI: https://doi.org/10.1124/pr.58.3.10
Ting-Chao Chou
Preclinical Pharmacology Core Laboratory, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York
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Article Information

vol. 58 no. 3 621-681
DOI 
https://doi.org/10.1124/pr.58.3.10
PubMed 
16968952

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 12, 2006.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ting-Chao Chou
  1. Preclinical Pharmacology Core Laboratory, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York
  1. Address correspondence to: Dr. Ting-Chao Chou, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021. E-mail: chout{at}mskcc.org
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Pharmacological Reviews: 58 (3)
Pharmacological Reviews
Vol. 58, Issue 3
1 Sep 2006
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OtherReview Article

Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

Ting-Chao Chou
Pharmacological Reviews September 1, 2006, 58 (3) 621-681; DOI: https://doi.org/10.1124/pr.58.3.10

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OtherReview Article

Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

Ting-Chao Chou
Pharmacological Reviews September 1, 2006, 58 (3) 621-681; DOI: https://doi.org/10.1124/pr.58.3.10
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  • Article
    • Abstract
    • I. Introduction
    • II. Theoretical Basis for Dose-Effect Analysis
    • III. Experimental Design for Drug Combinations
    • IV. Computerized Automation, Graphic Simulation, and Informatics
    • V. Selected Examples of Cited Applications
    • VI. Illustrations of Real Data Analysis with Mass-Action Law-Based Computer Software
    • Appendix I: Derivation of the Multiple Drug-Effect Equation
    • Glossary
    • Acknowledgments
    • Footnotes
    • References
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