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Research ArticleSpecial Issue IUPHAR Compendium of the Pharmacology and Classification of the Nuclear Receptor Superfamily 2006

International Union of Pharmacology. LXIV. Estrogen Receptors

Karin Dahlman-Wright, Vincent Cavailles, Suzanne A. Fuqua, V. Craig Jordan, John A. Katzenellenbogen, Kenneth S. Korach, Adriana Maggi, Masami Muramatsu, Malcolm G. Parker and Jan-Åke Gustafsson
Pharmacological Reviews December 2006, 58 (4) 773-781; DOI: https://doi.org/10.1124/pr.58.4.8
Karin Dahlman-Wright
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden (K.D.-W., J.-A.G.); Institut National de la Santé et de la Recherche Médicale U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France (V.C.); Baylor College of Medicine, Houston, Texas (S.A.F.); Fox Chase Cancer Center, Philadelphia, Pennsylvania (V.C.J.); University of Illinois at Urbana-Champaign, Urbana, Illinois (J.A.K.); National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (K.S.K.); Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy (A.M.); Research Center for Genomic Medicine, Saitama Medical School, Hidaka-shi, Saitama, Japan (M.M.); Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom (M.G.P.)
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Vincent Cavailles
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden (K.D.-W., J.-A.G.); Institut National de la Santé et de la Recherche Médicale U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France (V.C.); Baylor College of Medicine, Houston, Texas (S.A.F.); Fox Chase Cancer Center, Philadelphia, Pennsylvania (V.C.J.); University of Illinois at Urbana-Champaign, Urbana, Illinois (J.A.K.); National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (K.S.K.); Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy (A.M.); Research Center for Genomic Medicine, Saitama Medical School, Hidaka-shi, Saitama, Japan (M.M.); Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom (M.G.P.)
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Suzanne A. Fuqua
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden (K.D.-W., J.-A.G.); Institut National de la Santé et de la Recherche Médicale U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France (V.C.); Baylor College of Medicine, Houston, Texas (S.A.F.); Fox Chase Cancer Center, Philadelphia, Pennsylvania (V.C.J.); University of Illinois at Urbana-Champaign, Urbana, Illinois (J.A.K.); National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (K.S.K.); Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy (A.M.); Research Center for Genomic Medicine, Saitama Medical School, Hidaka-shi, Saitama, Japan (M.M.); Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom (M.G.P.)
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V. Craig Jordan
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden (K.D.-W., J.-A.G.); Institut National de la Santé et de la Recherche Médicale U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France (V.C.); Baylor College of Medicine, Houston, Texas (S.A.F.); Fox Chase Cancer Center, Philadelphia, Pennsylvania (V.C.J.); University of Illinois at Urbana-Champaign, Urbana, Illinois (J.A.K.); National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (K.S.K.); Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy (A.M.); Research Center for Genomic Medicine, Saitama Medical School, Hidaka-shi, Saitama, Japan (M.M.); Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom (M.G.P.)
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John A. Katzenellenbogen
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden (K.D.-W., J.-A.G.); Institut National de la Santé et de la Recherche Médicale U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France (V.C.); Baylor College of Medicine, Houston, Texas (S.A.F.); Fox Chase Cancer Center, Philadelphia, Pennsylvania (V.C.J.); University of Illinois at Urbana-Champaign, Urbana, Illinois (J.A.K.); National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (K.S.K.); Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy (A.M.); Research Center for Genomic Medicine, Saitama Medical School, Hidaka-shi, Saitama, Japan (M.M.); Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom (M.G.P.)
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Kenneth S. Korach
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden (K.D.-W., J.-A.G.); Institut National de la Santé et de la Recherche Médicale U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France (V.C.); Baylor College of Medicine, Houston, Texas (S.A.F.); Fox Chase Cancer Center, Philadelphia, Pennsylvania (V.C.J.); University of Illinois at Urbana-Champaign, Urbana, Illinois (J.A.K.); National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (K.S.K.); Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy (A.M.); Research Center for Genomic Medicine, Saitama Medical School, Hidaka-shi, Saitama, Japan (M.M.); Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom (M.G.P.)
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Adriana Maggi
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden (K.D.-W., J.-A.G.); Institut National de la Santé et de la Recherche Médicale U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France (V.C.); Baylor College of Medicine, Houston, Texas (S.A.F.); Fox Chase Cancer Center, Philadelphia, Pennsylvania (V.C.J.); University of Illinois at Urbana-Champaign, Urbana, Illinois (J.A.K.); National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (K.S.K.); Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy (A.M.); Research Center for Genomic Medicine, Saitama Medical School, Hidaka-shi, Saitama, Japan (M.M.); Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom (M.G.P.)
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Masami Muramatsu
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden (K.D.-W., J.-A.G.); Institut National de la Santé et de la Recherche Médicale U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France (V.C.); Baylor College of Medicine, Houston, Texas (S.A.F.); Fox Chase Cancer Center, Philadelphia, Pennsylvania (V.C.J.); University of Illinois at Urbana-Champaign, Urbana, Illinois (J.A.K.); National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (K.S.K.); Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy (A.M.); Research Center for Genomic Medicine, Saitama Medical School, Hidaka-shi, Saitama, Japan (M.M.); Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom (M.G.P.)
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Malcolm G. Parker
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden (K.D.-W., J.-A.G.); Institut National de la Santé et de la Recherche Médicale U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France (V.C.); Baylor College of Medicine, Houston, Texas (S.A.F.); Fox Chase Cancer Center, Philadelphia, Pennsylvania (V.C.J.); University of Illinois at Urbana-Champaign, Urbana, Illinois (J.A.K.); National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (K.S.K.); Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy (A.M.); Research Center for Genomic Medicine, Saitama Medical School, Hidaka-shi, Saitama, Japan (M.M.); Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom (M.G.P.)
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Jan-Åke Gustafsson
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden (K.D.-W., J.-A.G.); Institut National de la Santé et de la Recherche Médicale U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France (V.C.); Baylor College of Medicine, Houston, Texas (S.A.F.); Fox Chase Cancer Center, Philadelphia, Pennsylvania (V.C.J.); University of Illinois at Urbana-Champaign, Urbana, Illinois (J.A.K.); National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (K.S.K.); Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy (A.M.); Research Center for Genomic Medicine, Saitama Medical School, Hidaka-shi, Saitama, Japan (M.M.); Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom (M.G.P.)
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Article Information

vol. 58 no. 4 773-781
DOI 
https://doi.org/10.1124/pr.58.4.8
PubMed 
17132854

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online November 28, 2006.

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Pharmacological Reviews: 58 (4)
Pharmacological Reviews
Vol. 58, Issue 4
1 Dec 2006
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Research ArticleSpecial Issue IUPHAR Compendium of the Pharmacology and Classification of the Nuclear Receptor Superfamily 2006

International Union of Pharmacology. LXIV. Estrogen Receptors

Karin Dahlman-Wright, Vincent Cavailles, Suzanne A. Fuqua, V. Craig Jordan, John A. Katzenellenbogen, Kenneth S. Korach, Adriana Maggi, Masami Muramatsu, Malcolm G. Parker and Jan-Åke Gustafsson
Pharmacological Reviews December 1, 2006, 58 (4) 773-781; DOI: https://doi.org/10.1124/pr.58.4.8

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Research ArticleSpecial Issue IUPHAR Compendium of the Pharmacology and Classification of the Nuclear Receptor Superfamily 2006

International Union of Pharmacology. LXIV. Estrogen Receptors

Karin Dahlman-Wright, Vincent Cavailles, Suzanne A. Fuqua, V. Craig Jordan, John A. Katzenellenbogen, Kenneth S. Korach, Adriana Maggi, Masami Muramatsu, Malcolm G. Parker and Jan-Åke Gustafsson
Pharmacological Reviews December 1, 2006, 58 (4) 773-781; DOI: https://doi.org/10.1124/pr.58.4.8
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  • Article
    • Introduction
    • ER Expression
    • Mechanism of Transcriptional Activation
    • ERα and ERβ Promoters
    • Biologically Important Isoforms and Mutations
    • Functional Roles of ERs in Physiology and Disease
    • Structural Features of the Ligand-Binding Domain
    • Ligands
    • Current Evaluation of SERMs as Medicines
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