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Review ArticleReview Article

The Endomorphin System and Its Evolving Neurophysiological Role

Jakub Fichna, Anna Janecka, Jean Costentin and Jean-Claude Do Rego
Pharmacological Reviews March 2007, 59 (1) 88-123; DOI: https://doi.org/10.1124/pr.59.1.3
Jakub Fichna
Laboratory of Experimental Neuropsychopharmacology, Centre National de la Recherche Scientifique-Formation de Recherche en Evolution 2735, European Institute of Peptide Research (Institut Fédératif de Recherches Multidisciplinaires sur les Peptides 23), Faculty of Medicine and Pharmacy, Institute of Biomedical Research, University of Rouen, Rouen, France (J.F., J.C., J.-C.d.R.); and Laboratory of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (J.F., A.J.)
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Anna Janecka
Laboratory of Experimental Neuropsychopharmacology, Centre National de la Recherche Scientifique-Formation de Recherche en Evolution 2735, European Institute of Peptide Research (Institut Fédératif de Recherches Multidisciplinaires sur les Peptides 23), Faculty of Medicine and Pharmacy, Institute of Biomedical Research, University of Rouen, Rouen, France (J.F., J.C., J.-C.d.R.); and Laboratory of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (J.F., A.J.)
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Jean Costentin
Laboratory of Experimental Neuropsychopharmacology, Centre National de la Recherche Scientifique-Formation de Recherche en Evolution 2735, European Institute of Peptide Research (Institut Fédératif de Recherches Multidisciplinaires sur les Peptides 23), Faculty of Medicine and Pharmacy, Institute of Biomedical Research, University of Rouen, Rouen, France (J.F., J.C., J.-C.d.R.); and Laboratory of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (J.F., A.J.)
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Jean-Claude Do Rego
Laboratory of Experimental Neuropsychopharmacology, Centre National de la Recherche Scientifique-Formation de Recherche en Evolution 2735, European Institute of Peptide Research (Institut Fédératif de Recherches Multidisciplinaires sur les Peptides 23), Faculty of Medicine and Pharmacy, Institute of Biomedical Research, University of Rouen, Rouen, France (J.F., J.C., J.-C.d.R.); and Laboratory of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland (J.F., A.J.)
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Abstract

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) are two endogenous opioid peptides with high affinity and remarkable selectivity for the μ-opioid receptor. The neuroanatomical distribution of endomorphins reflects their potential endogenous role in many major physiological processes, which include perception of pain, responses related to stress, and complex functions such as reward, arousal, and vigilance, as well as autonomic, cognitive, neuroendocrine, and limbic homeostasis. In this review we discuss the biological effects of endomorphin-1 and endomorphin-2 in relation to their distribution in the central and peripheral nervous systems. We describe the relationship between these two μ-opioid receptor-selective peptides and endogenous neurohormones and neurotransmitters. We also evaluate the role of endomorphins from the physiological point of view and report selectively on the most important findings in their pharmacology.

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Pharmacological Reviews: 59 (1)
Pharmacological Reviews
Vol. 59, Issue 1
1 Mar 2007
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Review ArticleReview Article

The Endomorphin System and Its Evolving Neurophysiological Role

Jakub Fichna, Anna Janecka, Jean Costentin and Jean-Claude Do Rego
Pharmacological Reviews March 1, 2007, 59 (1) 88-123; DOI: https://doi.org/10.1124/pr.59.1.3

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Review ArticleReview Article

The Endomorphin System and Its Evolving Neurophysiological Role

Jakub Fichna, Anna Janecka, Jean Costentin and Jean-Claude Do Rego
Pharmacological Reviews March 1, 2007, 59 (1) 88-123; DOI: https://doi.org/10.1124/pr.59.1.3
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  • Article
    • Abstract
    • I. Introduction
    • II. Structure-Activity Relationship Studies
    • III. Distribution
    • IV. Receptors
    • V. Enzymatic Degradation
    • VI. Neurophysiological Role
    • VII. Conclusions
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