Review ArticleReview Article
G Protein-Coupled Receptor Trafficking in Health and Disease: Lessons Learned to Prepare for Therapeutic Mutant Rescue in Vivo
P. Michael Conn, Alfredo Ulloa-Aguirre, Joel Ito and Jo Ann Janovick
Pharmacological Reviews September 2007, 59 (3) 225-250; DOI: https://doi.org/10.1124/pr.59.3.2
P. Michael Conn
Divisions of Neuroscience and Reproductive Biology (P.M.C., A.U.-A., J.A.J.), Oregon National Primate Research Center (P.M.C., A.U.-A., J.I., J.A.J.), and Departments of Physiology and Pharmacology and Cell and Developmental Biology (P.M.C.), Oregon Health and Science University, Beaverton, Oregon; and Research Unit in Reproductive Medicine, Hospital de Ginecobstetricia “Luis Castelazo Ayala,” Instituto Mexicano del Seguro Social, Mexico City, Mexico (P.M.C., A.U.-A.)
Alfredo Ulloa-Aguirre
Divisions of Neuroscience and Reproductive Biology (P.M.C., A.U.-A., J.A.J.), Oregon National Primate Research Center (P.M.C., A.U.-A., J.I., J.A.J.), and Departments of Physiology and Pharmacology and Cell and Developmental Biology (P.M.C.), Oregon Health and Science University, Beaverton, Oregon; and Research Unit in Reproductive Medicine, Hospital de Ginecobstetricia “Luis Castelazo Ayala,” Instituto Mexicano del Seguro Social, Mexico City, Mexico (P.M.C., A.U.-A.)
Joel Ito
Divisions of Neuroscience and Reproductive Biology (P.M.C., A.U.-A., J.A.J.), Oregon National Primate Research Center (P.M.C., A.U.-A., J.I., J.A.J.), and Departments of Physiology and Pharmacology and Cell and Developmental Biology (P.M.C.), Oregon Health and Science University, Beaverton, Oregon; and Research Unit in Reproductive Medicine, Hospital de Ginecobstetricia “Luis Castelazo Ayala,” Instituto Mexicano del Seguro Social, Mexico City, Mexico (P.M.C., A.U.-A.)
Jo Ann Janovick
Divisions of Neuroscience and Reproductive Biology (P.M.C., A.U.-A., J.A.J.), Oregon National Primate Research Center (P.M.C., A.U.-A., J.I., J.A.J.), and Departments of Physiology and Pharmacology and Cell and Developmental Biology (P.M.C.), Oregon Health and Science University, Beaverton, Oregon; and Research Unit in Reproductive Medicine, Hospital de Ginecobstetricia “Luis Castelazo Ayala,” Instituto Mexicano del Seguro Social, Mexico City, Mexico (P.M.C., A.U.-A.)

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In this issue
Review ArticleReview Article
G Protein-Coupled Receptor Trafficking in Health and Disease: Lessons Learned to Prepare for Therapeutic Mutant Rescue in Vivo
P. Michael Conn, Alfredo Ulloa-Aguirre, Joel Ito and Jo Ann Janovick
Pharmacological Reviews September 1, 2007, 59 (3) 225-250; DOI: https://doi.org/10.1124/pr.59.3.2
Review ArticleReview Article
G Protein-Coupled Receptor Trafficking in Health and Disease: Lessons Learned to Prepare for Therapeutic Mutant Rescue in Vivo
P. Michael Conn, Alfredo Ulloa-Aguirre, Joel Ito and Jo Ann Janovick
Pharmacological Reviews September 1, 2007, 59 (3) 225-250; DOI: https://doi.org/10.1124/pr.59.3.2
Jump to section
- Article
- Abstract
- I. Introduction
- II. Endoplasmic Reticulum Quality Control System and Molecular Chaperones
- III. Physiology of the Gonadotropin-Releasing Hormone Receptor and Vasopressin Type 2 Receptor Systems
- IV. Ligand and Receptor Frequency Modulation in Signaling Systems: Implications for Model Selection and the Timing of Pharmacoperone Administration in Vivo
- V. Do Pharmacoperones Need to Be Present at the Time of Mutant Synthesis?
- VI. The Dominant-Negative Effect and Receptor Rescue
- VII. Will Pharmacoperone Drugs Be Species-Specific? Selecting the Correct Models for Drug Development
- VIII. Endogenous Chaperones as a Potential Site for Therapeutic Intervention
- IX. In Vitro and in Vivo Studies with Pharmacoperones: How Close Are We to the Transferring of Discoveries from the Laboratory Bench to the Bedside?
- X. Conclusions
- Acknowledgments
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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