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Review ArticleReview Article

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

Hiroyuki Kobori, Masaomi Nangaku, L. Gabriel Navar and Akira Nishiyama
Pharmacological Reviews September 2007, 59 (3) 251-287; DOI: https://doi.org/10.1124/pr.59.3.3
Hiroyuki Kobori
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana (H.K., L.G.N., A.N.); Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan (M.N.); and Department of Pharmacology and Hypertension and Kidney Disease Research Center, Kagawa University Medical School, Kagawa, Japan (A.N.)
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Masaomi Nangaku
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana (H.K., L.G.N., A.N.); Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan (M.N.); and Department of Pharmacology and Hypertension and Kidney Disease Research Center, Kagawa University Medical School, Kagawa, Japan (A.N.)
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L. Gabriel Navar
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana (H.K., L.G.N., A.N.); Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan (M.N.); and Department of Pharmacology and Hypertension and Kidney Disease Research Center, Kagawa University Medical School, Kagawa, Japan (A.N.)
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Akira Nishiyama
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana (H.K., L.G.N., A.N.); Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan (M.N.); and Department of Pharmacology and Hypertension and Kidney Disease Research Center, Kagawa University Medical School, Kagawa, Japan (A.N.)
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Pharmacological Reviews: 59 (3)
Pharmacological Reviews
Vol. 59, Issue 3
1 Sep 2007
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Review ArticleReview Article

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

Hiroyuki Kobori, Masaomi Nangaku, L. Gabriel Navar and Akira Nishiyama
Pharmacological Reviews September 1, 2007, 59 (3) 251-287; DOI: https://doi.org/10.1124/pr.59.3.3

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Review ArticleReview Article

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

Hiroyuki Kobori, Masaomi Nangaku, L. Gabriel Navar and Akira Nishiyama
Pharmacological Reviews September 1, 2007, 59 (3) 251-287; DOI: https://doi.org/10.1124/pr.59.3.3
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  • Article
    • Abstract
    • I. Introduction
    • II. Physiological Actions of Angiotensin II in the Kidney
    • III. Regulation of Circulating Renin-Angiotensin System—Classic Renin-Angiotensin System Pathways
    • IV. Mechanisms Responsible for Independent Regulation of Intrarenal Renin-Angiotensin System
    • V. Augmentation of the Intrarenal Renin-Angiotensin System during Progression of Hypertension and Renal Injury
    • VI. Effects of Pharmacological Intervention with Antihypertensive Agents on the Intrarenal Renin-Angiotensin System
    • VII. Conclusions
    • Acknowledgments
    • Footnotes
    • References
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