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Review ArticleReview Article

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

Hiroyuki Kobori, Masaomi Nangaku, L. Gabriel Navar and Akira Nishiyama
Pharmacological Reviews September 2007, 59 (3) 251-287; DOI: https://doi.org/10.1124/pr.59.3.3
Hiroyuki Kobori
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana (H.K., L.G.N., A.N.); Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan (M.N.); and Department of Pharmacology and Hypertension and Kidney Disease Research Center, Kagawa University Medical School, Kagawa, Japan (A.N.)
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Masaomi Nangaku
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana (H.K., L.G.N., A.N.); Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan (M.N.); and Department of Pharmacology and Hypertension and Kidney Disease Research Center, Kagawa University Medical School, Kagawa, Japan (A.N.)
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L. Gabriel Navar
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana (H.K., L.G.N., A.N.); Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan (M.N.); and Department of Pharmacology and Hypertension and Kidney Disease Research Center, Kagawa University Medical School, Kagawa, Japan (A.N.)
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Akira Nishiyama
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana (H.K., L.G.N., A.N.); Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan (M.N.); and Department of Pharmacology and Hypertension and Kidney Disease Research Center, Kagawa University Medical School, Kagawa, Japan (A.N.)
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Article Information

vol. 59 no. 3 251-287
DOI 
https://doi.org/10.1124/pr.59.3.3
PubMed 
17878513

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 18, 2007.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hiroyuki Kobori,
  2. Masaomi Nangaku,
  3. L. Gabriel Navar, and
  4. Akira Nishiyama
  1. Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana (H.K., L.G.N., A.N.); Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan (M.N.); and Department of Pharmacology and Hypertension and Kidney Disease Research Center, Kagawa University Medical School, Kagawa, Japan (A.N.)
  1. Address correspondence to: Dr. Hiroyuki Kobori, Associate Professor of Departments of Medicine and Physiology, Director of the Molecular Core in Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Ave., #SL39, New Orleans, LA 70112-2699. E-mail: hkobori{at}tulane.edu
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Pharmacological Reviews: 59 (3)
Pharmacological Reviews
Vol. 59, Issue 3
1 Sep 2007
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Review ArticleReview Article

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

Hiroyuki Kobori, Masaomi Nangaku, L. Gabriel Navar and Akira Nishiyama
Pharmacological Reviews September 1, 2007, 59 (3) 251-287; DOI: https://doi.org/10.1124/pr.59.3.3

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Review ArticleReview Article

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

Hiroyuki Kobori, Masaomi Nangaku, L. Gabriel Navar and Akira Nishiyama
Pharmacological Reviews September 1, 2007, 59 (3) 251-287; DOI: https://doi.org/10.1124/pr.59.3.3
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  • Article
    • Abstract
    • I. Introduction
    • II. Physiological Actions of Angiotensin II in the Kidney
    • III. Regulation of Circulating Renin-Angiotensin System—Classic Renin-Angiotensin System Pathways
    • IV. Mechanisms Responsible for Independent Regulation of Intrarenal Renin-Angiotensin System
    • V. Augmentation of the Intrarenal Renin-Angiotensin System during Progression of Hypertension and Renal Injury
    • VI. Effects of Pharmacological Intervention with Antihypertensive Agents on the Intrarenal Renin-Angiotensin System
    • VII. Conclusions
    • Acknowledgments
    • Footnotes
    • References
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